伊班膦酸钠与唑来膦酸治疗恶性肿瘤骨转移患者的效果比较  

Comparison of effects of Ibandronate sodium and Zoledronic acid in treatment of patients with malignant tumor bone metastasis

作　　者：邬勇斌 WU Yongbin(Third Department of Internal Medicine of Dongxiang District People’s Hospital,Fuzhou city,Fuzhou 331800 Jiangxi,China)

机构地区：[1]抚州市东乡区人民医院内三科,江西抚州331800

出　　处：《中国民康医学》2024年第19期146-148,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较伊班膦酸钠与唑来膦酸治疗恶性肿瘤骨转移患者的效果。方法:选取2022—2023年该院收治的104例恶性肿瘤骨转移患者进行前瞻性研究,采用随机数字表法将其分为对照组和研究组各52例。对照组采用唑来膦酸注射液治疗,研究组采用伊班膦酸钠注射液治疗。比较两组骨转移灶清退效果、治疗前后癌痛程度[数字分级评分法(NRS)]评分、骨相关事件(SREs)发生率和不良反应发生率。结果:研究组骨转移灶清退总有效率为86.54%(45/52),高于对照组的67.31%(35/52),差异有统计学意义(P<0.05);治疗12、24周后,两组NRS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组SREs发生率均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:伊班膦酸钠治疗恶性肿瘤骨转移患者可提高骨转移灶清退效果,以及降低癌痛程度评分和SREs发生率的效果优于唑来膦酸注射液治疗。Objective:To compare effects of Ibandronate sodium and Zoledronic acid in treatment of patients with malignant tumor bone metastasis.Methods:A prospective study was conducted on 104 patients with malignant tumor bone metastasis admitted to this hospital from 2022 to 2023.According to the random number table method,they were divided into control group and study group,52 cases in each group.The control group was treated with Zoledronic acid injection,while the study group was treated with Ibandronate sodium injection.The effects of bone metastasis clearance,the degree of cancer pain[numerical rating scale(NRS)]score before and after the treatment,the incidence of skeletal-related events(SREs),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of bone metastasis in the study group was 86.54%(45/52),which was higher than 67.31%(35/52)in the control group,and the difference was statistically significant(P<0.05).After 12 and 24 weeks of treatment,the NRS scores of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of SREs in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ibandronate sodium in the treatment of the patients with malignant tumor bone metastasis can improve the effects of bone metastasis clearance,and reduce the degree of cancer pain scores and the incidence of SREs.Moreover,it is superior to simple Zoledronic acid injection treatment.

关 键 词：伊班膦酸钠 唑来膦酸 恶性肿瘤骨转移 骨转移灶清退 癌痛程度 骨相关事件 不良反应 

分 类 号：R730.5[医药卫生—肿瘤]