手术应激促进肿瘤转移复发机制及潜在治疗策略的研究进展  

Research progress on the mechanism and potential treatment strategies of surgical stress promotes tumor recurrence and metastasis

作　　者：乞超 刘子龙[2] QI Chao;LIU Zilong(Department of Pharmacy,Wuhan No.1 Hospital,Wuhan 430022,China;Department of Forensic Medicine,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]武汉市第一医院药学部,武汉430022 [2]华中科技大学同济医学院法医学系,武汉430030

出　　处：《医学新知》2024年第9期1041-1048,共8页New Medicine

基　　金：武汉市科技局知识创新专项(2023020201010181);湖北省中医药管理局2023~2024年度中医药科研项目(ZY2023Q018)。

摘　　要：手术应激是促进肿瘤转移复发的关键因素之一,针对手术应激促进肿瘤转移复发的机制采取相应的治疗策略对改善肿瘤患者术后预后具有重要意义。本文对循环肿瘤细胞的脱落及定植、术后免疫微环境改变、术后机体内分泌激素水平变化等可能影响手术应激诱导肿瘤转移复发的机制进行总结,并概述术后机体激素水平和细胞因子调控、免疫治疗、肿瘤疫苗等相关的治疗策略,以期为肿瘤术后的转移复发的治疗提供参考。Surgical stress is one of the key factors that promote tumor metastasis and recurrence.Adopting corresponding treatment strategies based on the mechanism of surgical stress promoting tumor metastasis and recurrence is of great significance for improving the postoperative prognosis of tumor patients.This article summarized the mechanisms that may affect surgical stress-induced tumor metastasis and recurrences,such as shedding and colonization of circulating tumor cells,changes in postoperative immune microenvironment and postoperative endocrine hormone levels.It also outlined the treatment strategies related to postoperative hormone levels and cytokine regulation,immunotherapy,and tumor vaccines to provide references for the treatment of tumor metastasis and recurrence after surgery.

关 键 词：手术应激 肿瘤 复发 转移 治疗策略 

分 类 号：R730.7[医药卫生—肿瘤]