sIgE和sIgG4联合检测在过敏性疾病中的应用研究  

Study on the Application of Combined sIgE and sIgG4 Assay in Allergic Diseases

作　　者：张秀莲[1] 杨旭凯 陈晔 陈茂琳 陈祖阵 ZHANG Xiulian;YANG Xukai;CHEN Ye;CHEN Maolin;CHEN Zuzhen(Department of Laboratory,the Second Hospital of Sanming,Fujian Province,Sanming Fujian 366000,China;Department of Market,Hangzhou Zheda Dixun Biological Gene Engineering Co.,Ltd.,Hangzhou Zhejiang 310000,China;Department of Laboratory,Qingliu County General Hospital,Qingliu Fujian 365399,China;Department of Laboratory,Youxi County General Hospital,Youxi Fujian 365199,China;Reproductive Center,Sanming Integrated Medicine Hospital,Fujian Province,Sanming Fujian 353000,China)

机构地区：[1]福建省三明市第二医院检验科,福建三明366000 [2]杭州浙大迪迅生物基因工程有限公司市场部,浙江杭州310000 [3]清流县总医院检验科,福建清流365399 [4]尤溪县总医院检验科,福建尤溪365199 [5]福建省三明市中西医结合医院生殖中心,福建三明353000

出　　处：《中国卫生标准管理》2024年第17期117-121,共5页China Health Standard Management

摘　　要：目的了解过敏性疾病患者过敏原特异性IgE抗体(specific IgE,sIgE)和食物特异性IgG4抗体(specific IgG4,sIgG4)分布特点,为临床诊治提供依据。方法选取2022年5月19日—2023年11月14日在福建省三明市第二医院就诊的过敏性患者1617例为试验对象,联合检测sIgE、sIgG4。结果1617例过敏性患者中,sIgE阳性率为45.83%,sIgG4阳性率为75.02%,sIgE和s IgG4同时阳性占比为42.52%;s IgE检测中吸入性过敏原阳性率户尘螨/粉尘螨最高,为34.45%;食入性过敏原牛奶最高,为8.23%;sIgG4检测阳性率前两位为鸡蛋、牛奶,分别为66.54%、47.68%。sIgE致敏程度集中在1~2级,以1种阳性为主,sIgG4致敏程度集中在3级,以2种阳性为主。男性户尘螨/粉尘螨、蟑螂、混合草、牛奶、蟹和虾sIgE阳性率均高于女性(P<0.05),牛奶、鳕鱼和小麦sIgG4阳性率均高于女性(P<0.05);成年组户尘螨/粉尘螨、混合草和牛奶sIgE阳性率均低于未成年组(P<0.05);牛奶、鸡蛋、大豆、鳕鱼和小麦sIgG4阳性率均显著低于未成年组(P<0.05);通过医生指导过敏原干预后症状改善者占比88.89%。结论sIgE和sIgG4联合检测对防治过敏具有重要的指导意义,通过检测指导干预能有效改善症状。Objective To characterize the distribution of allergen-specific IgE antibody(sIgE)and food-specific IgG4 antibody(sIgG4)in patients with allergic diseases,and to provide a basis for clinical diagnosis and treatment.Methods A total of 1617 allergic patients who visited the Second Hospital of Sanming,Fujian Province from May 19,2022 to November 14,2023 were selected as the experimental subjects,and serum allergen specific IgE antibodies and food specific IgG4 antibodies were jointly detected.Results Among 1617 allergic patients,sIgE positive rate was 45.83%,sIgG4 positive rate was 75.02%,and IgE and sIgG4 were positive at the same time accounted for 42.52%;inhalation allergen positive rate of house dust mite/powder dust mite was the highest in the sIgE test at 34.45%,and the highest in the ingested allergen,milk,was 8.23%,and the top two positive rate in the sIgG4 test was eggs and milk,66.54%and 47.68%,respectively;sIgE sensitization degree was concentrated in level 1-2,with one type of positive,and sIgG4 sensitization degree was concentrated in level 3,with two types of positive rate;the positive rates of house dust mite/powdery mildew mite,cockroach,mixed grasses,milk,crabs,and shrimps for sIgE in males were significantly higher than that in females(P<0.05),and the positive rate of sIgG4 in milk,cod,and wheat were significantly higher than that of females(P<0.05),while the positive rates of milk,cod,and wheat were significantly higher than that of females(P<0.05).Positive rates were significantly higher than those of females(P<0.05);positive rates of house dust mite/powdery mildew mite,mixed grass and milk sIgE were significantly lower in the adult group than those of the immature group(P<0.05),and positive rates of milk,egg,soy,cod and wheat sIgG4 were significantly lower in the adult group than those of the immature group(P<0.05);and the percentage of those whose symptoms improved after allergen intervention through doctor′s guidance was 88.89%.Conclusion Combined sIgE and sIgG4 testing is important in guidi

关 键 词：过敏性疾病 过敏原 特异性IGE 特异性IGG4 联合检测 饮食干预 

分 类 号：R781[医药卫生—口腔医学]