含奈妥匹坦帕洛诺司琼胶囊方案预防肺癌顺铂化疗相关恶心呕吐的临床疗效  

Clinical Efficacy of Netupitant and Palonosetron Hydrochloride Capsules Regimen in Preventing Chemotherapy-induced Nausea and Vomiting Associated with Cisplatin Chemotherapy for Lung Cancer

作　　者：陈晋[1] CHEN Jin(Oncology Department,Quanzhou Hospital of Traditional Chinese Medicine,Quanzhou 362000,China)

机构地区：[1]泉州市中医院肿瘤内科,福建泉州362000

出　　处：《中国医学创新》2024年第26期36-40,共5页Medical Innovation of China

摘　　要：目的:探究含奈妥匹坦帕洛诺司琼胶囊方案预防肺癌顺铂化疗相关恶心呕吐(CINV)的临床疗效。方法:回顾性收集2021年8月—2023年12月于泉州市中医院接受含顺铂方案化疗治疗的80例肺癌患者的临床资料,按照不同的治疗方案分为两组,对照组40例采取静脉用甲磺酸多拉司琼注射液联合地塞米松预防CINV,观察组40例采用口服奈妥匹坦帕洛诺司琼胶囊联合地塞米松预防CINV,比较两组患者化疗期间恶心呕吐严重程度(恶心呕吐缓解率)、药物不良反应及化疗后生活质量变化情况。结果:观察组恶心呕吐缓解率较对照组高(P<0.05)。两组治疗期间药物不良反应发生率比较,差异无统计学意义(P>0.05)。观察组化疗后恶心呕吐生活功能指数量表(FLIE)的两个分量表评分和总分均较对照组高,差异均有统计学意义(P<0.001)。结论:预防性使用含奈妥匹坦帕洛诺司琼胶囊止吐方案可有效改善含顺铂方案CINV的严重程度,提升患者生活质量。Objective:To explore the clinical efficacy of Netupitant and Palonosetron Hydrochloride Capsules regimen in preventing Cisplatin chemotherapy-induced nausea and vomiting(CINV)of lung cancer.Method:Clinical data of 80 patients with lung cancer who received Cisplatin chemotherapy in Quanzhou Hospital of Traditional Chinese Medicine from August 2021 to December 2023 were retrospectively collected,they were divided into two groups according to different treatment regiments,40 patients in the control group were given intravenous Dolasetron Mesylate Injection combined with Dexamethasone to prevent CINV;40 patients in the observation group were given oral Netupitant and Palonosetron Hydrochloride Capsules combined with Dexamethasone to prevent CINV.The severity of nausea and vomiting(remission rate of nausea and vomiting),adverse drug reactions and changes in quality of life after chemotherapy were compared between the two groups.Result:The nausea and vomiting remission rate of observation group was higher than that of control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).The scores of the two subscales and total scores of the functional living index-emesis(FLIE)after chemotherapy in the observation group were higher than those in the control group,the differences were statistically significant(P<0.001).Conclusion:Prophylactic use of Netupitant and Palonosetron Hydrochloride Capsules antiemetic regimen can effectively improve the severity of CINV of Cisplatin regimen,improve the quality of life of patients,and do not increase the incidence of adverse reactions.

关 键 词：奈妥匹坦帕洛诺司琼胶囊 顺铂 化疗相关恶心呕吐 

分 类 号：R734.2[医药卫生—肿瘤]