经皮穴位电刺激治疗老年认知功能障碍的效果  

Effect of Transcutaneous Acupoint Electrical Stimulation for Elderly Cognitive Dysfunction

作　　者：季韧 张柳柳 JI Ren;ZHANG Liuliu(Department of Geriatrics,Qidong People's Hospital,Qidong 226200,China;不详)

机构地区：[1]启东市人民医院(南通大学附属启东医院)老年医学科,江苏启东226200 [2]启东市第六人民医院全科,江苏启东226200

出　　处：《中国医学创新》2024年第26期45-48,共4页Medical Innovation of China

摘　　要：目的:探讨经皮穴位电刺激治疗老年认知功能障碍的效果及对其血清β分泌酶1(BACE1)、超氧化物歧化酶1(SOD1)水平的影响。方法:选择2020年7月—2023年7月启东市人民医院收治的115例老年认知功能障碍患者,按照乱数表法分为对照组(n=57)和观察组(n=58),对照组给予常规药物治疗,观察组在对照组基础上给予经皮穴位电刺激治疗。观察两组认知功能、血清因子(BACE1、SOD1)水平、颅内动脉血流速度[大脑中动脉(MCA)、基底动脉(BA)、椎动脉(VA)血流速度]及日常生活能力。结果:治疗前,两组蒙特利尔认知评估量表(MoCA)评分、日常生活活动能力(ADL)评分及MCA、BA、VA血流速度及SOD1、BACE1水平比较,差异均无统计学意义(P>0.05);治疗后,观察组MoCA评分、MCA、BA、VA血流速度及SOD1、BACE1水平均明显高于对照组,ADL评分明显低于对照组,差异均有统计学意义(P<0.05)。结论:老年认知功能障碍患者应用经皮穴位电刺激治疗,不仅能够有效改善认知功能,升高血清SOD1、BACE1水平,还能改善血流动力学,提高日常生活能力。Objective:To investigate the effect of transcutaneous acupoint electrical stimulation on elderly cognitive dysfunction and its influence on serum β-site APP cleaving enzyme 1(BACE1),superoxide dismutase 1(SOD1)levels.Method:A total of 115 elderly patients with cognitive dysfunction admitted to Qidong People's Hospital from July 2020 to July 2023 were selected and divided into control group(n=57)and observation group(n=58)according to random number table method.The control group was given conventional drug treatment,and the observation group was given transcutaneous acupoint electrical stimulation on the basis of the control group.Cognitive function,serum factors(BACE1,SOD1)levels,intracranial arterial blood flow velocity[middle cerebral artery(MCA),basilar artery(BA),vertebral artery(VA)blood flow velocity]and daily living ability of the two groups were observed.Result:Before treatment,there were no significant differences in Montreal cognitive assessment scale(MoCA)scores,activity of daily living(ADL)scores,MCA,BA,VA blood flow velocity and the levels of SOD1,BACE1 between the two groups(P>0.05).After treatment,MoCA score,MCA,BA,VA blood flow velocity and the levels of SOD1,BACE1 in the observation group were significantly higher than those in the control group,and ADL score was significantly lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:The application of transcutaneous acupoint electrical stimulation in elderly patients with cognitive dysfunction can not only effectively improve cognitive function,increase the level of serum SOD1 and BACE1,but also improve hemodynamics and improve the ability of daily living.

关 键 词：认知功能障碍 老年患者 低频电刺激仪 血清因子 颅内动脉血流速度 

分 类 号：R749.1[医药卫生—神经病学与精神病学]