穴位埋线辅助四联疗法治疗脾胃虚弱型慢性萎缩性胃炎伴Hp感染临床研究  

Clinical Study on Catgut Embedment in Acupoint Assisting Quadruple Therapy for Chronic Atrophic Gastritis Complicated with Hp Infection of Spleen-Stomach Weakness Type

作　　者：刘兵[1] 钱小情[1] 李丽乐 王健[1] 杨艳 LIU Bing;QIAN Xiaoqing;LI Lile;WANG Jian;YANG Yan(Lishui Hospital of Traditional Chinese Medicine,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市中医院,浙江丽水323000

出　　处：《新中医》2024年第18期157-161,共5页New Chinese Medicine

基　　金：丽水市公益性科研计划项目(2023GYX59)。

摘　　要：目的:观察穴位埋线辅助四联疗法治疗脾胃虚弱型慢性萎缩性胃炎(CAG)伴幽门螺杆菌(Hp)感染的临床疗效。方法:选取112例脾胃虚弱型CAG伴Hp感染患者,采用随机数字表法分为对照组(予四联疗法治疗)和观察组(予穴位埋线辅助四联疗法治疗)各56例。治疗结束后,2组均随访5个月。比较2组临床疗效、胃黏膜功能指标[胃泌素17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)]、健康调查简表(SF-36)评分、中医证候积分、病理评分、不良反应发生率及复发率。结果:总有效率观察组96.43%,高于对照组80.36%(P<0.05)。治疗后3个月,2组血清G-17、PGⅠ水平均较治疗前升高(P<0.05),观察组上述2项指标水平均高于对照组(P<0.05)。治疗后1个月、3个月,2组SF-36评分均较治疗前升高(P<0.05),观察组SF-36评分均高于同期对照组(P<0.05)。治疗后3个月,2组中医证候积分均较治疗前降低(P<0.05),观察组中医证候积分低于对照组(P<0.05)。治疗后5个月,2组病理评分均较治疗前下降(P<0.05),观察组病理评分低于对照组(P<0.05)。不良反应发生率观察组8.93%,与对照组3.57%比较,差异无统计学意义(P>0.05)。治疗后5个月,复发率观察组1.85%,低于对照组15.56%(P<0.05)。结论:穴位埋线辅助四联疗法治疗脾胃虚弱型CAG伴Hp感染,可减轻患者的临床症状,改善胃黏膜功能,提高生活质量,降低复发率,且安全性好。Objective:To observe the clinical effect of catgut embedment in acupoint assisting quadruple therapy on chronic atrophic gastritis(CAG)complicated with helicobacter pylori(Hp)infection of spleen-stomach weakness type.Methods:A total of 112 cases of CAG complicated with Hp infection patients of spleen-stomach weakness type were selected and divided into the control group(treated with quadruple therapy)and the observation group(treated with catgut embedment in acupoint assisting quadruple therapy),with 56 cases in each group,using a random number table method.After treatment,both groups were followed up for five months.Compared with the clinical efficacy,gastric mucosal function indicators[gastrin 17(G-17)and pepsinogenⅠ(PGⅠ)],36-Item Short Form Health Survey(SF-36)scores,traditional Chinese medicine(TCM)syndrome scores,pathological scores,incidence of adverse reactions,and recurrence rates between the two groups.Results:The total effective rate was 96.43%in the observation group,which was higher than that of 80.36%in the control group(P<0.05).Three months after treatment,the levels of G-17 and PGⅠin serum in both groups were increased when compared with those before treatment(P<0.05),and the levels of the above two indicators in the observation group were higher than those in the control group(P<0.05).One month and three months after treatment,the SF-36 scores in both groups were increased when compared to those before treatment(P<0.05),and the SF-36 score in the observation group was higher than that in the control group during the same period(P<0.05).Three months after treatment,the TCM syndrome scores in the two groups were decreased when compared to those before treatment(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).Five months after treatment,the pathological scores in both groups were declined when compared to those before treatment(P<0.05),and the pathological score in the observation group was lower than that in the control group(P<0.05)

关 键 词：慢性萎缩性胃炎 幽门螺杆菌 脾胃虚弱型 穴位埋线 四联疗法 胃黏膜功能 生活质量 

分 类 号：R573.32[医药卫生—消化系统] R245.91[医药卫生—内科学]