细胞程序性死亡在结直肠癌中的研究进展  

Research progress of programmed cell death in colorectal cancer

作　　者：吴小超[1] 荣龙飞 唐睿漪 王飞[1] 缪林[1] WU Xiaochao;RONG Longfei;TANG Ruiyi;WANG Fei;MIAO Lin(Department of Gastroenterology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China)

机构地区：[1]南京医科大学第二附属医院消化医学中心,江苏南京210011 [2]南京医科大学附属逸夫医院普外科,江苏南京210000

出　　处：《中国临床研究》2024年第9期1313-1318,共6页Chinese Journal of Clinical Research

摘　　要：细胞程序性死亡是一种重要的生物学过程,包括凋亡、自噬等多种方式,对于维持组织和器官的平衡至关重要。近年来,多项研究表明细胞程序性死亡的异常调控在结直肠肿瘤的发生发展中发挥重要作用。因此,揭示细胞程序性死亡在结直肠癌发生和发展中的精细调控网络对开发新的结直肠癌临床诊疗策略具有重要意义。本文就细胞程序性死亡在结直肠癌中的研究进展作一综述,以期为结直肠癌的临床诊治提供新的思路和方法。Programmed cell death is an important biological process,including apoptosis,autophagy and other modalities,which is essential for maintaining homeostasis of tissue and organ.In recent years,several studies have shown that aberrant regulation of programmed cell death plays an important role in the development of colorectal cancer.Therefore,it is important to reveal the fine-turned regulatory network of programmed cell death in colorectal carcinogenesis and progression to develop new clinical treatment strategies for colorectal cancer.This paper aims to review the research progress of programmed cell death in colorectal cancer,and provide new ideas and approaches for the clinical diagnosis and treatment of colorectal cancer.

关 键 词：细胞程序性死亡 结直肠癌 凋亡 自噬 铁死亡 坏死 焦亡 

分 类 号：R735.3[医药卫生—肿瘤]