自拟芪参消疲方治疗肺癌癌因性疲乏的临床疗效观察  

Clinical Observation on Qishen Xiaopi Decoction in Treating Cancer Related Fatigue of Lung Cancer

作　　者：沈云博 李鑫[1] 周玲羚 殷九旭 李晓丹[3] 刘伟[3] SHEN Yunbo;LI Xin;ZHOU Lingling;YIN Jiuxu;LI Xiaodan;LIU Wei(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Xi’an Hospital of Traditional Chinese Medicine,Shaanxi Xi’an 710001,China;The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China)

机构地区：[1]天津中医药大学,天津301617 [2]陕西省西安市中医医院,陕西西安710001 [3]天津中医药大学第二附属医院,天津300250

出　　处：《中医药临床杂志》2024年第9期1762-1767,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：天津市教委科研计划项目(2021ZD018);天津市中医药重点领域科研项目(2022010);第二批天津市中医经典传承高级人才研修项目(津卫中〔2022〕375号)。

摘　　要：目的:观察芪参消疲方对肺脾两虚型肺癌癌因性疲乏患者的临床疗效。方法:将90例患者根据病情分为对照组、治疗组1、治疗组2各30人。观察3组患者治疗前后Piper评分、中医证候积分、血常规、EORTC QLQ-C30评分、BFI评分等疗效指标以及安全性指标。结果:3组患者Piper疲乏评分、中医症候积分、QLQ-C30评分、BFI评分,治疗后较治疗前均有所改善,但治疗组1与治疗组2均优于对照组。对照组总有效率为36.67%,治疗组1总有效率为93.33%,治疗组2总有效率为76.67%。对照组血常规未见明显变化,治疗组1白细胞、红细胞、血红蛋白较前明显升高,治疗组2红细胞、血红蛋白、红细胞压积、血小板较前明显降低。且治疗组1红细胞高于治疗组2及对照组、血红蛋白高于治疗组2,治疗组2红细胞、红细胞压积均低于对照组。结论:芪参消疲方能够有效减轻肺脾两虚型肺癌癌因性疲乏患者的疲乏症状、改善临床指标,减少联合抗肿瘤治疗引起的不良反应的发生,且安全有效,值得临床推广。Objective:To observe the clinical efficacy of Qishen Xiaopi prescription on patients with lung cancerrelated fatigue of lung and spleen deficiency type.Methods:A total of 90 patients were divided into control group,treatment group 1 and treatment group 2 according to their condition,with 30 patients in each group.The efficacy indexes and safety indexes such as Piper score,TCM syndrome score,blood routine test,EORTC QLQ-C30 score,BFI score were observed in the three groups before and after treatment.Results:Piper fatigue score,TCM syndrome score,QLQ-C30 score and BFI score of the three groups were improved after treatment compared with those before treatment,but the treatment groups 1 and 2 were better than the control group.The total effective rate of the control group was 36.67%,the total effective rate of the treatment group 1 was 93.33%,and the total effective rate of the treatment group 2 was 76.67%.There was no significant change in the blood routine of the control group.The white blood cells,red blood cells,and hemoglobin of treatment group 1 were significantly higher than before,and the red blood cells,hemoglobin,hematocrit,and platelets of treatment group 2 were significantly lower than before.The red blood cells of treatment group 1 were higher than those of treatment group 2 and the control group,and the hemoglobin was higher than that of treatment group 2.The red blood cells and hematocrit of treatment group 2 were lower than those of the control group.Conclusion:Qishen Xiaopi Recipe can effectively alleviate the fatigue symptoms of patients with lung and spleen deficiency type lung cancer-related fatigue,improve clinical indicators,and reduce the occurrence of adverse reactions caused by combined anti-tumor therapy.It is safe and effective,and worthy of clinical promotion.

关 键 词：肺癌 癌因性疲乏 肺脾气虚 益气健脾 芪参消疲方 中医药 疗效观察 

分 类 号：R734.2[医药卫生—肿瘤]