不同剂量注射用奥美拉唑钠治疗急性消化性溃疡出血疗效分析  

Clinical Efficacy of Omeprazole Sodium for Injection at Different Doses in the Treatment of Acute Peptic Ulcer Bleeding

作　　者：孙雪岩 王文磊 SUN Xueyan;WANG Wenlei(Emergency Department,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000,China)

机构地区：[1]河南科技大学第一附属医院急诊科,河南洛阳471000

出　　处：《中国烧伤创疡杂志》2024年第5期413-416,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的探讨不同剂量注射用奥美拉唑钠治疗急性消化性溃疡出血的临床疗效。方法选取2021年5月至2022年5月河南科技大学第一附属医院收治的72例急性消化性溃疡出血患者作为研究对象,按照药物不同治疗剂量将其分为高剂量组(36例)和常规剂量组(36例),高剂量组患者常规内镜下止血后予以80 mg注射用奥美拉唑钠静脉滴注,常规剂量组患者常规内镜下止血后予以40 mg注射用奥美拉唑钠静脉滴注,对比观察两组患者止血时间、住院时间、临床疗效、胃内pH值变化情况及再出血率。结果高剂量组患者止血时间和住院时间均明显短于常规剂量组(t=2.213、3.158,P=0.030、0.002);治疗3 d后,高剂量组患者总有效率为83.33%,明显高于常规剂量组患者的总有效率61.11%(χ^(2)=4.431,P=0.035);高剂量组患者24 h胃内pH值与常规剂量组无明显差异(t=0.786,P=0.434),但pH值达4.0和6.0所需时间均明显短于常规剂量组(t=2.072、2.321,P=0.042、0.023);治疗后随访1个月,高剂量组患者再出血率为11.11%,明显低于常规剂量组患者的再出血率30.56%(χ^(2)=4.126,P=0.042)。结论与常规剂量注射用奥美拉唑钠相比,高剂量注射用奥美拉唑钠更能有效控制急性消化性溃疡出血患者出血症状,缩短止血时间和住院时间,快速提高胃内pH值,降低再出血率,疗效更显著。Objective To study the clinical efficacy of omeprazole sodium for injection at different doses in the treatment of acute peptic ulcer bleeding.Methods 72 patients with acute peptic ulcer bleeding,admitted to The First Affiliated Hospital of Henan University of Science and Technology from May 2021 to May 2022,were enrolled as research subjects and divided into the high-dose group(n=36)and the routine dose group(n=36)based on the treatment dose.Patients in the high-dose group received an 80 mg intravenous drip of omeprazole sodium after routine endoscopic hemostasis,whereas patients in the routine dose group received a 40 mg intravenous drip of omeprazole sodium after routine endoscopic hemostasis.Hemostasis time,length of stay,clinical efficacy,change of intragastric pH value,and rebleeding rate were compared between the two groups.Results The hemostasis time and length of stay of patients were significantly shorter in the high-dose group compared with the routine dose group(t=2.213 and 3.158,P=0.030 and 0.002).After 3 days of treatment,the total effective rate of patients was 83.33%in the high-dose group,which was significantly higher than the corresponding 61.11%in the routine dose group(χ^(2)=4.431,P=0.035).There was no significant difference in the 24-hour intragastric pH value between the two groups(t=0.786,P=0.434),but the time required to reach a pH value of 4.0 and 6.0 was significantly shorter in the high-dose group(t=2.072 and 2.321,P=0.042 and 0.023).One-month follow-up after treatment showed that the rebleeding rate in the high-dose group was 11.11%,which was significantly lower than the corresponding 30.56%in the routine dose group(χ^(2)=4.126,P=0.042).Conclusion Compared with routine dose,high-dose omeprazole sodium for injection can effectively control bleeding symptoms of patients with acute peptic ulcer bleeding,shorten hemostasis and hospitalization time,increase intragastric pH value rapidly,and reduce the rebleeding rate,and the clinical efficacy is more definite.

关 键 词：不同剂量 奥美拉唑钠 急性消化性溃疡出血 止血 再出血 

分 类 号：R573.1[医药卫生—消化系统]