缺血性脑卒中神经血管单元研究热点与趋势的文献计量可视化分析  

Bibliometric visualization analysis of research hotspots and trends in neurovascular unit of ischemic stroke

作　　者：但存燕 戎梦玮 夏天晴 丁智斌 江楠 马存根[3] 宋丽娟 DAN Cunyan;RONG Mengwei;XIA Tianqing;DING Zhibin;JIANG Nan;MA Cungen;SONG Lijuan(不详;The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Selerosis of State Administration of Traditional Chinese Medicine/Research Center of Neuroloiology,Shaxi University of Chinese Medicine,Jinzhong 030619,China;Department of Neurosurgery,Sinopharm Tongmei General Hospital,Datong Shanxi 037003,China)

机构地区：[1]山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室/神经生物学研究中心,030619 [2]山西白求恩医院(山西医学科学院同济山西医院)山西医科大学第三医院,030032 [3]山西大同大学脑科学研究所/附属第一医院神经科,037009 [4]国药同煤集团总医院神经外科,037003

出　　处：《中国神经免疫学和神经病学杂志》2024年第5期376-382,414,共8页Chinese Journal of Neuroimmunology and Neurology

基　　金：国家自然科学基金项目(82004028、81473577);中国博士后科学基金面上资助项目(2020M680912);山西中医药大学2022年度科技创新团队项目(2022TD2010);山西省卫健委医学科技领军团队项目(2020TD05);山西中医药大学附属医院国家区域中医医疗中心心血管专项基金项目(XGZX202115);山西中医药大学青年科学家培育项目(2021PY-QN-09);山西省科技创新人才青年团队项目(202204051001028);国家中医药管理局张仲景传承与创新专项(GZY-KJS-2022-048-1);山西中医药大学2023年研究生教育创新项目(2023CX025);山西省研究生科研实践类项目(2023KY678)。

摘　　要：目的分析全球视野下缺血性脑卒中神经血管单元(neurovascular unit,NVU)的研究进展和未来趋势,以期为该领域的研究者提供参考。方法检索2003-1-1—2023-6-30 Web of science核心数据库收录的有关缺血性脑卒中NVU的研究文献,运用文献计量学方法从发文趋势、发文作者、发文机构、关键词共现、发文期刊等角度对收集的文献进行定量和定性分析。采用VOSviewer软件绘制关键词共现图谱,采用Citespace软件生成爆发词图谱。结果共纳入716篇文献,发表在267种期刊中,共涉及41个国家、801家研究机构、3271名作者。近年来,该研究领域发文趋势不断上升,高被引文章显示引用前10的文献研究内容主要聚焦缺血性脑卒中后血脑屏障、神经炎症、小胶质细胞和星形胶质细胞方面。涉及3340个关键词,其中有67个关键词至少出现了20次,结合2017—2023年爆发词分析显示,其中“细胞凋亡”“血脑屏障”“中医药”“信号通路”“胶质细胞”等关键信息在此阶段受到广泛关注。结论有关缺血性脑卒中NVU研究逐渐引起学者关注,神经元可以接受NVU其他组分的信号调节,通过靶向NVU、保护血脑屏障完整性可减少缺血性脑卒中后细胞凋亡,发挥神经保护作用,这为新药的研发提供了可能性;此外探索针对NVU的缺血性脑卒中发生的生物标志物或许能为缺血性脑卒中疾病鉴定提供更为全面的依据。Objective To understand and analyze the research progress and future trend of neurovascular unit(NVU)in ischemic stroke from a global perspective,in order to provide references for researchers in this field.Methods The literature on NVU in ischemic stroke was retrieved from the Web of science core database from 2003-1-1 to 2023-6-30.Quantitative and qualitative analysis was conducted from the perspectives of publication trend,author,publication institution,keyword co-occurrence and publication journal by using bibliometrics.VOSviewer software was used to draw the keyword co-occurrence graph,and Citespace software was used to generate the outburst word graph.Results A total of 716 articles were included,published in 267 journals,involving 41 countries,and 3271 authors from 801 institutions.In recent years,the trend of published papers in this research field has been increasing,and highly cited articles showed that the top 10 cited literatures mainly focus on the blood-brain barrier,neuroinflammation,microglia and astrocytes after ischemic stroke,involving 3340 keywords,67 of which appeared at least 20 times.Combined with the 2017—2023 burst word analysis showed that″apoptosis″,″blood-brain barrier″,″traditional Chinese medicine″,″signaling pathway″,″glial cells″and other key information received wide attention at this stage.Conclusions The research on NVU in ischemic stroke has gradually attracted the attention of scholars.Neurons can accept the signal modulation of other components of NVU.By targeting NVU and protecting the integrity of blood-brain barrier,apoptosis of cells after ischemic stroke will be reduced and neuroprotective effect will be fully played.This opens up possibilities for the development of new drugs.In addition,exploring the biomarkers of ischemic stroke occurrence in NVU may provide a more comprehensive basis for the identification of ischemic stroke diseases.

关 键 词：缺血性脑卒中 神经血管单元 WOS数据库 VOSviewer 文献计量学 可视化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]