主观认知障碍的胃癌患者语言流畅性损害研究  

The study of semantic verbal fluency impairment in gastric cancer patients with subjective cognitive decline

作　　者：解佳奇 陈仿军[1] 陶伟 蒋俊[3] 辛恺 常睿敏 谭思怡 牛百慧 XIE Jiaqi;CHEN Fangjun;TAO Wei;JIANG Jun;XIN Kai;CHANG Ruimin;TAN Siyi;NIU Baihui(不详;Department of Oncology,Gulou Hospital Affiliated to Nanjing University School of Medicine,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院肿瘤科,南京210008 [2]江苏省人民医院浦口分院肿瘤科 [3]安徽医科大学第一附属医院肿瘤科

出　　处：《中国临床保健杂志》2024年第4期472-474,共3页Chinese Journal of Clinical Healthcare

基　　金：国家自然科学基金项目(81902911)。

摘　　要：目的研究存在主观认知障碍(SCD)的胃癌患者的语言流畅性,为早期干预轻度认知功能障碍患者提供依据。方法招募存在主观认知下降的胃癌患者46例为SCD组,记忆力正常者50例为对照组,2组均行全面神经心理及语言流畅测试(VFT),VFT测试包括语音、语义流畅性测试。除总分外还考察了前后30 s的得分、语义流畅性中的聚类和转换指数次数。结果SCD组语义转换测试中动物及蔬菜聚类大小更小(t=-2.705,P=0.008;t=-9.780,P<0.001),SCD组蔬菜转换次数更少(t=-10.266,P<0.001),2组其他项目得分差异无统计学意义。结论在SCD胃癌患者中,定量语言流畅性测试敏感性好,预测轻度认知障碍可行语义流畅性测试。Objective To study the verbal fluency of patients with gastric cancer with subjective cognitive decline(SCD),and to provide a reference for early intervention of mild cognitive impairmen.Methods A total of 46 gastric cancer patients with subjective cognitive decline were recruited as SCD group and 50 patients with normal memory as control group.Verbal Fluency Test(VFT)was performed in both groups.VFT test included speech and semantic fluency test.In addition to the total score,the number of clustering and conversion exponents in semantic fluency were also examined.Results Gastric c-ancer patients with SCD generated fewer clusters in vegeta getables and animals category(t=-2.705,P=0.008;t=-9.780,P<0.001).They perfo-rmed less switches in vegetables categor(t=-10.266,P<0.001).There was no difference in other scores between the two groups.Conclusions In gastric cancer patients with SCD,the quantitative VFT has good sensitivity and can predict the feasibility of semantic fluency test in mild cognitive impairment.

关 键 词：胃肿瘤 认知功能障碍 言语障碍 老年人 

分 类 号：R735.2[医药卫生—肿瘤]