基于Web of Science数据库的2011-2023年结直肠癌自噬研究文献计量分析  

Bibliometric analysis of autophagy research in colorectal cancer from 2011 to 2023 based on Web of Science

作　　者：李渊婷 魏振宏[1] 罗添 贾晶[1] 魏超君[1] LI Yuanting;WEI Zhenhong;LUO Tian;JIA Jing;WEI Chaojun(NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor,the Institute of Clinical Research and Translational Medicine,Gansu Provincial Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃省人民医院国家卫生健康委胃肠肿瘤诊治重点实验室/临床研究与转化医学研究所,甘肃兰州730000

出　　处：《中国普通外科杂志》2024年第8期1300-1310,共11页China Journal of General Surgery

基　　金：甘肃省科技厅青年科技计划基金资助项目(21JR7RA651);甘肃省人民医院院内科研基金资助项目(20GSSY4-38)。

摘　　要：背景与目的:结直肠癌(CRC)是全球高发肿瘤,化疗耐药是临床治疗的难点,调控CRC自噬可以改善肿瘤细胞耐药性,因此自噬成为CRC备受关注的研究领域。本研究通过文献计量分析探讨2011—2023年全球CRC自噬研究领域热点及趋势,为该领域的研究热点和趋势提供参考依据。方法:从Web of Science数据库中检索CRC自噬的相关文献,用RefWorks格式导出全记录和引文参考文献,将导出的数据导入CiteSpace及VOSviewer软件中,对2011—2023年CRC自噬研究领域发表文献的年度、国家、机构、作者、期刊、被引情况以及关键词等进行可视化分析,分析该领域研究热点及研究趋势。结果:2011—2023年共发表1758篇文献,文献发表量呈上升趋势,其中发文量排名前五位的国家是中国、美国、韩国、日本和意大利;发表文章数量前五位的机构分别是中山大学、上海交通大学、复旦大学、南方医科大学、中国医科大学;发表文献数量前五位的作者分别是Zhou Shufeng、He Zhixu、Yang Yinxue、Zhou Zhiwei、Zhang Xueji;共被引前五位的期刊分别是Autophagy、Cancer Research、Cell、Journal of Biological Chemistry、Nature;在CRC自噬相关研究中被引次数最多的是2008年Beth Levine等发表的Autophagy in the pathogenesis of disease;CRC自噬与治疗和预后的关系,CRC自噬分子机制的研究,调控CRC自噬寻找化疗药物作用靶点为该领域的研究热点;CRC自噬研究的新趋势是:非编码RNA、肠道微生态及肿瘤微环境与CRC自噬的相互作用。结论:CRC自噬主要研究的热点是相关信号通路对CRC生物学功能的作用,以及寻找新的药物作用靶点调控CRC自噬从而提高CRC的治疗效果,探究非编码RNA、肠道微生态及肿瘤微环境与CRC自噬的相互作用将成为未来的研究趋势。Background and Aims:Colorectal cancer(CRC)is a highly prevalent tumor worldwide,and chemotherapy resistance poses a significant challenge in its clinical treatment.Regulating autophagy in CRC can counteract tumor cell resistance to chemotherapy,making autophagy a prominent research focus in CRC studies.This study was conducted to investigate the global research trends and hotspots in the field of CRC autophagy from 2011 to 2023 through a bibliometric analysis,to provide a reference for identifying key research areas and future directions in this field.Methods:Relevant literature on CRC autophagy was retrieved from the Web of Science database and exported in RefWorks format,including full records and citation references.The data was then imported into CiteSpace and VOSviewer software for visualization analysis of annual publications,countries,institutions,authors,journals,citation status,and keywords from 2011 to 2023 to identify research hotspots and trends in this field.Results:A total of 1758 papers were published between 2011 and 2023,showing an upward trend in publication volume.The top five countries in terms of publication volume were China,the United States,South Korea,Japan,and Italy.The top five institutions with the highest number of publications were Sun Yat-sen University,Shanghai Jiao Tong University,Fudan University,Southern Medical University,and China Medical University.The top five authors with the most publications were Zhou Shufeng,He Zhixu,Yang Yinxue,Zhou Zhiwei,and Zhang Xueji.The top five co-cited journals were Autophagy,Cancer Research,Cell,Journal of Biological Chemistry,and Nature.The most frequently cited study in CRC autophagy research is the 2008 work by Beth Levine and colleagues titled"Autophagy in the Pathogenesis of Disease".Research hotspots in the field included the relationship between CRC autophagy and treatment and prognosis,molecular mechanisms of CRC autophagy,and identifying targets for chemotherapy drugs by regulating CRC autophagy.Emerging trends in CRC autophagy researc

关 键 词：结直肠肿瘤 自噬 文献计量学 数据可视化 

分 类 号：R735.3[医药卫生—肿瘤]