时间依赖弥散MRI用于肿瘤研究进展  

Research progresses of time-dependent diffusion MRI in tumors

作　　者：赵雪莲 严家豪 贾非 张静[1,2,3] 刘光耀 ZHAO Xuelian;YAN Jiahao;JIA Fei;ZHANG Jing;LIU Guangyao(Department of Magnetic Resonance,the Second Hospital&Clinical Medical School,Lanzhou University,Lanzhou 730030,China;Gansu Province Clinical Research Center for Functional and Molecular Imaging,Lanzhou 730030,China;Gansu Medical Nuclear Magnetic Resonance Equipment Application Industry Technology Center,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院(第二临床医学院)核磁共振科,甘肃兰州730030 [2]甘肃省功能及分子影像临床医学研究中心,甘肃兰州730030 [3]甘肃省医用核磁共振装备应用行业技术中心,甘肃兰州730030

出　　处：《中国医学影像技术》2024年第9期1440-1443,共4页Chinese Journal of Medical Imaging Technology

基　　金：2023年陇原青年创新创业人才项目(2023LQGR28);甘肃省功能及分子影像临床医学研究中心(21JR7RA438)。

摘　　要：弥散加权成像是用于诊断和评估疾病治疗效果的重要影像学技术,但其主要关注水分子整体扩散而忽略了其微观运动和组织微观结构。时间依赖弥散MRI(t_(d)-dMRI)利用振荡梯度自旋回波和脉冲梯度自旋回波序列组合获取不同扩散时间的MRI信号,以捕获不同微观结构的信息;随着MR硬件设备的快速发展,近年已进入临床应用阶段。本文就t_(d)-dMRI技术原理及其在肿瘤中的应用进展进行综述。Diffusion weighted imaging is an important imaging technique for diagnosing and evaluating the effectiveness of disease treatment,mainly focusing on the overall diffusion behavior of water molecules but ignoring the microscopic movement of water molecules and the details of tissue microstructures.Combining oscillatory gradient spin-echo and pulsed gradient spin echo sequences,time-dependent diffusion MRI(t_(d)-dMRI)captured diffusion MRI signals at varying time,in order to obtain information of different microstructures,which had recently emerged into clinical application with the advancements of hardware.The principles of t_(d)-dMRI technology and its application progresses in tumors were reviewed in this article.

关 键 词：肿瘤 磁共振成像 

分 类 号：R73[医药卫生—肿瘤] R445.2[医药卫生—临床医学]