肠道固有免疫屏障与致病菌逃避肠道固有免疫清除的基因调控策略  

Intestinal innate immune barrier and genetic regulatory mechanisms employed by enteropathogenic bacteria to evade innate immune system in intestines

作　　者：李思嘉 连思琪 闫丽 夏芃芃 LI Sijia;LIAN Siqi;YAN Li;XIA Pengpeng(Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses/International Research Laboratory of Prevention and Control of Important Animal Infectious Diseases and Zoonotic Diseases of China,Institute of Comparative Medicine,College of Veterinary Medicine,Yangzhou University,Yangzhou,Jiangsu 225009,China)

机构地区：[1]扬州大学兽医学院比较医学研究院江苏省动物重要疫病与人兽共患病防控协同创新中心/江苏高校动物重要疫病和重要人兽共患病防控技术国际合作联合实验室,江苏扬州225009

出　　处：《中国兽医学报》2024年第6期1299-1306,1315,共9页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(32072820,31702242);扬州大学本科生创新训练资助项目(X20220708);江苏高校优势学科建设工程资助项目。

摘　　要：肠道致病菌利用自身毒力因子干扰肠上皮细胞功能,并通过精密的基因调控策略躲避宿主免疫系统的清除,进而引发多种疾病。研究发现毒素—抗毒素系统、分泌系统以及群体感应系统均可以影响病原菌的基因表达策略;而越来越多的新型抑菌策略通过干扰细菌自身的基因调控系统,抑制细菌的毒力基因表达,能够达到温和地治疗肠道疾病的目的。本文首先从肠道固有免疫的组成入手,针对肠道致病菌的基因调控系统展开论述,阐述肠道致病菌利用自身基因调控逃避固有免疫清除的机制,旨在为治疗肠道细菌性疾病提供新的研究思路。Intestinal pathogenic bacteria utilize their own virulence factors to interfere with the normal function of intestinal epithelial cells and evade clearance by the host immune system through precise gene regulation and expression strategies,thereby causing a variety of diseases.It has been found that the mechanisms affecting the gene expression strategies of pathogens include the toxin-antitoxin system,secretory system,and quorum sensing system.Novel antimicrobial strategies are being developed to interfere with the inherent gene regulatory system of bacteria and inhibit the expression of virulence genes,thus enabling a modest approach to the treatment of intestinal diseases.This paper initially discusses the components of innate immunity in the gut,followed by a discussion of the common gene regulatory system of intestinal pathogenic bacteria.This article aims to clarify the mechanisms by which intestinal pathogenic bacteria evade clearance by the innate immune system through gene regulation and expression strategies,and to provide new ideas for the treatment of intestinal bacterial diseases.

关 键 词：肠道致病菌 固有免疫 基因调控 群体感应 

分 类 号：S852.61[农业科学—基础兽医学]