多聚ADP核糖聚合酶1在口腔鳞状细胞癌精准诊疗中的作用机制及转化价值  

The importance of poly(ADP⁃ribose)polymerase 1 in precision medicine of oral squamous cell carcinoma

作　　者：曾德荣 马琳 李星瀚 胡伟涛 刘琦[2,4] 邓永强 Zeng Derong;Ma Lin;Li Xinghan;Hu Weitao;Liu Qi;Deng Yongqiang(Department of Stomatology,Shenzhen University General Hospital,Shenzhen University,Shenzhen 518055,China;Institute of Stomatological Research,Shenzhen University,Shenzhen 518055,China;School of Stomatology,Hangzhou Normal University,Hangzhou 311121,China;International Cancer Center,School of Medicine,Shenzhen University,Shenzhen 518055,China)

机构地区：[1]深圳大学总医院口腔科,深圳518055 [2]深圳大学口腔医学研究所,深圳518055 [3]杭州师范大学口腔医学院,杭州311121 [4]深圳大学医学部国际肿瘤中心,深圳518055

出　　处：《中华口腔医学研究杂志（电子版）》2024年第4期269-275,共7页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：国家自然科学基金(82073007、82373212);广东省基础与应用基础研究基金(2023A1515011945)。

摘　　要：缺少有效分子靶点是阻碍口腔鳞状细胞癌(OSCC)精准诊疗进步的关键因素。多聚ADP核糖聚合酶1(PARP1)具有执行DNA损伤反应、处理氧化应激压力、抑制细胞程序性死亡等功能,是癌细胞应对生存压力的重要工具,也是适用于多种癌症治疗的分子靶点。研究显示,PARP1在OSCC诊疗中具有强大的潜力:一方面PARP1分子显像技术可用于OSCC的在体诊断,另一方面PARP抑制剂与放化疗联合应用在OSCC临床前测试中取得了良好的疗效。本文总结了PARP1在癌症治疗中的作用机制,重点阐述了PARP1应用于OSCC精准诊疗的研究进展,以促进PARP1靶点在OSCC中的临床应用转化。The lack of effective molecular targets is a critical problem hindering the advance of precision medicine in oral squamous cell carcinoma(OSCC).Poly(ADP⁃ribose)polymerase 1(PARP1)is a pleiotropic gene involved in several cellular functions,e.g.,executing DNA damage response,processing oxidative stress,and inhibiting programmed cell death,making it an important tool for cancer cells to cope with survival pressures and a molecular target suitable for the treatment of various cancers.Recent research progress has shown that PARP1 has great potential in the diagnosis and treatment of OSCC.On one hand,molecular imaging techniques can be used for the in vivo diagnosis of PARP1 expression and distribution.On the other hand,the combined application of PARP inhibitors with radiochemotherapy has achieved great therapeutic effects in preclinical tests.This article summarized the mechanisms of PARP1 in cancer treatment,with a focus on elucidating the research progress in the precision medicine of OSCC using PARP1 as a molecular target,to promote the clinical application of PARP1 targeting in the treatment of OSCC.

关 键 词：口腔肿瘤 多聚ADP核糖聚合酶1 多(ADP核糖)聚合酶抑制剂 精准医学 分子显像 

分 类 号：R739.8[医药卫生—肿瘤]