食管癌患者血清白介素17、微小核糖核酸424水平与临床病理参数和预后的关系  

The relationship between the levels of serum interleukin-17 and miRNA 424 and the clinicopathological parameters and prognosis in patients with esophageal cancer

作　　者：丁青青 李玉娟[1] 闫芳 朱慧芳 DING Qing-qing;LI Yu-juan;YAN Fang;ZHU Hui-fang(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450000

出　　处：《实用医院临床杂志》2024年第5期126-130,共5页Practical Journal of Clinical Medicine

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20231127)。

摘　　要：目的探讨食管癌(EC)患者血清白介素17(IL-17)、微小核糖核酸424(miRNA 424)表达情况及与临床病理参数和预后的关系。方法我院收治的223例EC患者,收集一般临床资料及病理资料,入院后采集空腹静脉血,检测血清IL-17、miRNA 424水平,比较不同病理特征下EC患者血清IL-17、miRNA 424水平,分析血清miRNA 424水平与EC临床病理参数的关系;术后随访3年,根据患者生存状况分为生存组(n=152)和死亡组(n=71),比较两组血清IL-17、miRNA 424水平,采用受试者工作特征(ROC)曲线分析血清IL-17、miRNA 424水平对EC患者预后的预测价值。结果不同年龄、肿瘤直径、TNM分期、分化程度、浸润深度、淋巴结转移患者血清IL-17、miRNA 424水平比较差异有统计学意义(P<0.05);血清IL-7、miRNA 424表达水平与EC TNM分期、分化程度、浸润深度、淋巴结转移呈正相关(P<0.05);生存组IL-17、miRNA 424水平低于死亡组(P<0.05);IL-17、miRNA 424单独及联合预测EC患者预后的敏感度分别为77.46%、74.65%、88.73%,特异度分别为65.13%、62.50%、61.84%,AUC分比为0.755、0.734、0.835,联合诊断价值更高。结论EC患者IL-17、miRNA 424与疾病临床分期、分化程度、浸润深度、淋巴结转移均具有显著相关性,且二者对患者预后具有较高的诊断价值。Objective To explore the expressions of serum interleukin-17(IL-17)and micro ribonucleic acid 424(miRNA 424)in patients with esophageal cancer(EC)and their relationship with clinicopathological parameters and prognosis.Methods Two hundred and twenty-four patients with EC in our hospital were selected.The general clinical data and pathological data of the patients were collected.The fasting venous blood of patients was collected after admission,and the levels of serum IL-17 and miRNA 424 were detected.The levels of serum IL-17 and miRNA 424 in EC patients with different pathological characteristics were compared.The relationship between serum miRNA 424 levels and EC clinicopathological parameters was analyzed.The patients were followed up for 3 years after surgery.According to the survival status of patients,they were classified into a survival group(n=152)and a death group(n=71).The levels of serum IL-17 and miRNA 424 were compared between the two groups.Receiver operating characteristic(ROC)curve was adopted to analyze the predictive value of serum IL-17 and miRNA 424 levels for prognosis of EC patients.Results There were significant differences in the expressions of serum IL-17 and miRNA 424 in different ages,tumor diameter,TNM staging,differentiation degree,depth of invasion and lymph node metastasis(P<0.05).The expression levels of serum IL-7 and miRNA 424 were significantly positively correlated with TNM staging,differentiation degree,depth of invasion and lymph node metastasis of EC(P<0.05).The levels of IL-17 and miRNA 424 in the survival group were significantly lower than those in death group(P<0.05).The sensitivities of IL-17 and miRNA 424 alone and in combination in the prediction of prognosis of EC patients were 77.46%,74.65%and 88.73%,and the specificities were 65.13%,62.50%and 61.84%,and the AUCs were 0.755,0.734 and 0.835,respectively.The combined diagnostic value was higher.Conclusions Serum IL-17 and miRNA 424 in EC patients are significantly correlated with clinical staging,differentiation degre

关 键 词：食管癌 白介素17 微小核糖核酸424 病理参数 预后 

分 类 号：R735.1[医药卫生—肿瘤]