经尿道钬激光膀胱肿瘤切除术联合表柔比星膀胱灌注化疗对膀胱癌患者肿瘤标志物的影响  

Effect of transurethral holmium laser bladder tumor resection combined with epirubicin bladder infusion chemotherapy on tumor markers in patients with bladder cancer

作　　者：刘博文 唐迎九[2] LIU Bo-wen;TANG Ying-jiu(Department of Urology,Branch of Tianjin Third Central Hospital,Tianjin 300250,China;不详)

机构地区：[1]天津市第三中心医院分院泌尿外科,天津300250 [2]天津市第三中心医院泌尿外科,天津300170

出　　处：《中国处方药》2024年第9期109-112,共4页Journal of China Prescription Drug

摘　　要：目的探讨经尿道钬激光膀胱肿瘤切除术+表柔比星膀胱灌注化疗联合治疗对膀胱癌患者肿瘤标志物的影响。方法将天津市第三中心医院本部及医院分院建档时间为2020年10月~2023年11月的100例膀胱癌患者,根据治疗方法的不同分为对照组(经尿道钬激光膀胱肿瘤切除术治疗,n=50)和研究组(经尿道钬激光膀胱肿瘤切除术+表柔比星膀胱灌注化疗,n=50)。评估两组临床疗效、肿瘤标志物水平、生活质量、不良事件发生情况、复发情况等指标的变化差异。结果研究组临床总有效率(84.00%)高于对照组(66.00%)(P<0.05);治疗后,研究组肿瘤标志物水平、生活质量各维度评分均优于对照组(P<0.05);研究组不良事件发生率、复发率均低于对照组(P<0.05)。结论膀胱癌患者采用经尿道钬激光膀胱肿瘤切除术联合表柔比星膀胱灌注化疗,其肿瘤标志物水平、生活质量均得到明显改善,且疗效显著,不良事件发生风险低,复发率低。Objective To investigate the effect of transurethral holmium laser bladder tumor resection plus epirubicin bladder infusion chemotherapy on tumor markers in patients with bladder cancer.Methods 100 cases of bladder cancer patients in Tianjin Third Central Hospital and the Branch of Tianjin Third Central Hospital from October 2020 to November 2023 were divided into the control group(transurethral holmium laser bladder tumor resection,n=50)and the study group(transurethral holmium laser bladder tumor resection+epirubicin bladder infusion chemotherapy,n=50)due to their different treatment methods.The difference of clinical efficacy,tumor marker level,quality of life,occurrence of adverse events and recurrence between the two groups was evaluated.Results Compared with the control group(66.00%),the total clinical effective rate of the study group(84.00%)was higher(P<0.05).Compared with before treatment,the level of tumor markers and scores of quality of life in the study group after treatment were better than those in the control group(P<0.05).Compared with the control group(16.00%and 18.00%),the incidence of adverse events(4.00%)and recurrence(6.00%)in the study group were lower(P<0.05).Conclusion After transurethral holmium laser bladder tumor resection and epirubicin bladder infusion chemotherapy combined,tumor marker levels and quality of life of patients with bladder cancer were significantly improved,and the efficacy was significant,with low risk of adverse events and low recurrence rate.

关 键 词：经尿道钬激光膀胱肿瘤切除术 表柔比星膀胱灌注化疗 膀胱癌 肿瘤标志物水平 生活质量 

分 类 号：R737.14[医药卫生—肿瘤]