Comparison of different surrogate markers of muscle mass for the diagnosis of sarcopenia in patients with colorectal cancer  

作　　者：Jia-Le Li Qi Zhou Qi-WenWang De-Cheng Luo Jiang-Hong Huang Xin-Long Yu Si-Zhi Liang Shuang-Yi Tang Jia-Liang Gan 

机构地区：[1]Department of Pharmacy,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China [2]Department of Colorectal and Anal Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China [3]Grade 2020,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China

出　　处：《Journal of Nutritional Oncology》2024年第1期25-36,共12页肿瘤营养学杂志（英文）

基　　金：supported by the Guangxi Medical and Health Appropriate Technology Development and Application Project(No.S2021095);Undergraduate Enrollment Project of Guangxi Medical University(No.S202410598186).

摘　　要：Background:This study compared the validity of the creatinine-to-cystatin C ratio(CCR),sarcopenia index(SI),and relative skeletalmuscle index(RSMI)as predictors of sarcopenia in patients with colorectal cancer(CRC)and explored their impact on the patient prognosis.Methods:We retrospectively studied patients with CRC who underwent surgical intervention at the Department of Colorectal and Anal Surgery,situatedwithin the First Affiliated Hospital of GuangxiMedical University.The investigation spanned from January 2015 to December 2017,encompassing a cohort of patients subject to surgical management forCRC during this period.Pearson’s correlation analysis was employed to evaluate the relationships between the CCR,SI,RSMI,and skeletal muscle index(SMI)and the patient prognosis.Receiver operating characteristic(ROC)curves were generated to evaluate the predictive precision of these biomarkers and ascertain the optimal cutoff values.Multivariate logistic regression analysis was conducted to pinpoint the independent factors linked with sarcopenia.Survival analyses,contingent on different surrogate markers of muscle mass and sarcopenia,were performed utilizing the Kaplan-Meier method alongside the log-rank test.Results:Weenrolled 815 patientswithCRC(522 male and 293 female patients)whowere eligible for the analysis.In accordancewith the guidelines set forth by the International Consensus on Sarcopenia,sarcopenia was diagnosed in a collective total of 503 patients.A Pearson’s correlation coefficient(r)analysis demonstrated that the CCR,SI,and RSMI were positively correlated with the SMI.In both male and female patients,the RSMI(male:r=0.400,P<0.001;female:r=0.640,P<0.001)was more strongly correlated with the SMI than with the CCR(male:r=0.203,P<0.001;female:r=0.192,P<0.001)or SI(male:r=0.335,P<0.001;female:r=0.285,P<0.001).In male patients,the areas under the ROC curves(AUC)for the CCR,SI,and RSMI were 0.596[(95%confidence interval(CI)=0.545-0.647)],0.648(95%CI=0.599-0.698),and 0.681(95%CI=0.629-0.733),respectively.In

关 键 词：Colorectal cancer Creatinine-to-cystatin C ratio Sarcopenia index Relative skeletal muscle index SARCOPENIA 

分 类 号：R73[医药卫生—肿瘤]