现代制药综合实验课程设计的探索与实践——以白藜芦醇为例  

Exploration and practice of comprehensive experiment of modern pharmaceutics course design:A case study on resveratrol

作　　者：陶俊妃 郑雁芬 张晓金 何雪涵 姚美村 TAO Junfei;ZHENG Yanfen;ZHANG Xiaojin;HE Xuehan;YAO Meicun(School of Pharmaceutical Sciences(Shenzhen),SunYat-senUniversity,Shenzhen 518107,China)

机构地区：[1]中山大学药学院(深圳),广东深圳518107

出　　处：《实验技术与管理》2024年第9期222-229,共8页Experimental Technology and Management

基　　金：2023年度中山大学校级教学质量与教学改革工程项目(中大教务[2023]96号)。

摘　　要：该文以白藜芦醇为例,通过对提取分离、原料药质量分析、制剂制备及质量评价等全过程的实验设计和实施,以及课后总结和研讨等环节,阐述了“现代制药综合实验”课程理念。该课程旨在将实践与理论相结合,激发学生对药学科研的兴趣和主动创新精神,学会综合分析问题和解决问题的方法,提升统筹规划能力,加强团队合作精神,为将来的科研等专业性工作打下坚实基础。[Objective]A comprehensive experiment of modern pharmaceutics is a vital part of the pharmacy course at Sun Yat-sen University,which is“Double First-Class,”because it enhances the professional competence of undergraduate students comprehensively.The course has been practiced for numerous years,and good teaching results have been recorded.To summarize and improve the overall experience,an experiment involving the extraction and separation,quality analysis of resveratrol,preparation and quality analysis of formulations,and teaching discussions was conducted using resveratrol as an example.[Methods]The comprehensive experiment of modern pharmaceutics primarily involves the following stages.First,the responsible teachers designate the compound to be extracted or synthesized,and the students choose the method,team up,and then analyze and summarize the literature and draft an initial scheme.Then,the students revise the experimental scheme under the guidance of the teachers and determine the experimental scheme after verifying its feasibility through preliminary experiments.Next,they enter the experimental phase as follows.First,resveratrol is extracted using either the alkaline extraction-acid precipitation method or the ultrasound-assisted enzymatic hydrolysis method according to the students’experimental scheme.Resveratrol is separated and purified by extraction and silica gel column chromatography,and the structure of the product is analyzed and identified using an infrared(IR)spectrometer and nuclear magnetic resonance spectrometer(NMR).Second,the quality evaluation of the raw materials,including the description,identification,loss on drying,residue after ignition,heavy metal,and content determination,is conducted.The high-performance liquid chromatography method is realized to determine the resveratrol content.Third,resveratrol microemulsion and resveratrol microemulsion gel are prepared according to the prescribed formula and process.The quality analysis of the pharmaceutical preparations is conducted,inclu

关 键 词：教学改革 课程设计与实践 白藜芦醇 药学 

分 类 号：R9[医药卫生—药学] G642.0[文化科学—高等教育学]