Naples预后评分对食管鳞癌患者根治性放疗预后的预测价值  

Prognostic value of Naples prognostic score in esophageal squamous cell carcinoma patients receiving definitive radiotherapy

作　　者：付神波 金龙[2] 邵帅 郭俊俊 Fu Shenbo;Jin Long;Shao Shuai;Guo Junjun(Department of Radiation Oncology,Shaanxi Provincial Cancer Hospital,Xi'an 710061,China;Department of Radiation Oncology,Shaanxi Provincial People's Hospital,Xi'an 710068,China)

机构地区：[1]陕西省肿瘤医院放疗科,陕西西安710061 [2]陕西省人民医院放疗科,陕西西安710068

出　　处：《实用肿瘤杂志》2024年第5期442-450,共9页Journal of Practical Oncology

基　　金：陕西省重点研发计划一般项目-社会发展领域(2022SF-495)。

摘　　要：目的探讨Naples预后评分(Naples prognostic score,NPS)对食管鳞癌患者根治性放疗预后的预测价值。方法收集2014年1月至2018年12月在陕西省肿瘤医院行根治性放疗的220例食管鳞癌患者。根据治疗前血清白蛋白、总胆固醇、中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)和淋巴细胞/单核细胞比值(lymphocyte-monocyte ratio,LMR)计算NPS。根据NPS将患者分为低危组(0分)、中危组(1或2分)和高危组(3或4分)。采用Kaplan-Meier法绘制生存曲线并行log-rank检验,采用Cox比例风险回归模型进行单因素和多因素分析。结果NPS低危组、中危组和高危组患者的5年总生存(overall survival,OS)率分别为47.0%、37.7%和16.3%,5年无进展生存(progression free survival,PFS)率分别为42.4%、30.4%和16.2%(均P<0.01)。多因素分析显示,性别、T分期、治疗方式和NPS均是影响患者OS的独立危险因素,而T分期和NPS均是影响患者PFS的独立危险因素(均P<0.05)。结论治疗前NPS对行根治性放疗的食管鳞癌患者预后有良好预测价值。Objective To evaluate the prognostic value of Naples prognostic score(NPS)in esophageal squamous cell carcinoma patients receiving definitive radiotherapy.Methods The data of 220 esophageal squamous cell carcinoma patients receiving definitive radiotherapy at Shaanxi Provincial Cancer Hospital from January 2014 to December 2018 were collected.NPS was calculated based on serum albumin,total cholesterol,neutrophil-lymphocyte ratio(NLR),and lymphocyte-monocyte ratio(LMR).According to NPS,patients were divided into low-risk group(patients with NPS of 0),middle-risk group(patients with NPS of 1 or 2),and high-risk group(patients with NPS of 3 or 4).Kaplan-Meier curves and log-rank test were used for survival analysis.The prognostic factors of the patients were analyzed by univariate and multivariate Cox regression analysis.Results The 5-year overall survival(OS)rates of patients in the low-,middle-,and high-risk groups were 47.0%,37.7%,and 16.3%,respectively,and the 5-year progression free survival(PFS)rates were 42.4%,30.4%,and 16.2%,respectively(both P<0.01).Multivariate analysis demonstrated that gender,T stage,treatment modalities,and NPS were independent factors of OS,and T stage and NPS were independent factors of PFS(all P<0.05).Conclusions Pretreatment NPS has a good predictive value for the prognosis of esophageal squamous cell carcinoma patients receiving definitive radiotherapy.

关 键 词：食管鳞癌 放疗 Naples预后评分 预后 

分 类 号：R735.1[医药卫生—肿瘤]