甘肃省6~12岁儿童甲状腺容积影响因素及不同甲状腺容积校正方法比较  

Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods

作　　者：徐利花 费秀兰 陈发青 李青林 孙玮[1] 王涛 王燕玲[1] XU Lihua;FEI Xiulan;CHEN Faqing;LI Qinglin;SUN Wei;WANG Tao;WANG Yanling(Institute of Endemic Diseases,Gansu Provincial Centre for Disease Control and Prevention,Lanzhou 730000,China;Nanchong City Hospital of Traditional Chinese Medicine Medical Department,Nanchong 637000,China)

机构地区：[1]甘肃省疾病预防控制中心地方病所,兰州730000 [2]南充市中医医院医务科,南充637000

出　　处：《中华疾病控制杂志》2024年第8期917-921,987,共6页Chinese Journal of Disease Control & Prevention

基　　金：甘肃省卫生行业科研计划项目(GSWSKY2021-008)。

摘　　要：目的 分析甘肃省6~12岁儿童甲状腺容积的影响因素,探讨适宜的甲状腺容积校正方法。方法 根据甘肃省2019年碘缺乏病监测结果,选择碘营养适宜的武威市凉州区和平凉市崆峒区作为调查点。采用多阶段分层抽样方法抽取非寄宿制6~12岁儿童(地区、性别比例均衡),测量儿童的身高、体重、甲状腺容积、尿碘和所在家庭食用盐盐碘。分析儿童甲状腺容积影响因素,比较体质容积指数(body mass volume index, BMIV)、体表面积容积指数(body surface area volume index, BSAV)、体重身高容积指数(weight height volume index, WHVI)、身高容积指数1(height volume index1, HVI1)和身高容积指数2(height volume index2, HVI2)对甲状腺容积校正的效果。结果 不同性别儿童甲状腺容积差异无统计学意义(Z=-0.837,P=0.403)。Spearman秩相关分析显示身高、体重、BMI、体表面积(body surface area, BSA)、年龄、尿碘与甲状腺容积均呈正相关(均P<0.001)。其中,BSA与甲状腺容积相关性最强(r=0.787)。分位数回归分析显示年龄和BSA对甲状腺容积整体分布均有影响。通过身高、体重与校正后甲状腺容积的Spearman秩相关分析显示BSAV可最大程度减小身高、体重对甲状腺容积的影响。结论 年龄和BSA均影响甲状腺容积。BSAV对儿童甲状腺容积校正效果较好,建议将其作为儿童甲状腺容积的评价指标。Objective To analyze the influencing factors of thyroid volume at children aged 6-12 years in Gansu Province,and to explore the appropriate correction method of thyroid volume.Methods Based on the results of the 2019 iodine deficiency disease monitoring in Gansu Province,Liangzhou District of Wuwei City and Kongtong District of Pingliang City,where iodine nutrition is appropriate,were selected as survey sites.A multi-stage stratified sampling method was used to extract non-residential children aged 6-12 years(with balanced regional and gender ratio).The height,weight,thyroid volume,urinary iodine and salt iodine in their families were measured.The influencing factors of thyroid volume in children were analyzed.The thyroid volume correction effects of body mass volume index(BMIV),body surface area volume index(BSAV),weight height volume index(WHVI),height volume index(WHVI),height volume index1(HVI1)and height volume index2(HVI2)were compared.Results Thyroid volume was not statistically significant when children of different genders(Z=-0.837,P=0.403).Spearman rank correlation analysis showed that height,body weight,BMI,body surface area(BSA),age,urinary iodine were positively correlated with thyroid volume(P<0.001).Among them,BSA had the strongest correlation with thyroid volume(r=0.787).Quantile regression analysis showed that age and BSA had significant effects on the overall distribution of thyroid volume.Spearman rank correlation analysis of height,weight and corrected thyroid volume showed that BSAV could eliminate the influence of height and weight on thyroid volume to the greatest extent.Conclusions Age and BSA significantly affected thyroid volume.BSAV has a good correction effect on children′s thyroid volume,and it is recommended to be used as an evaluation index of children′s thyroid volume.

关 键 词：儿童 甲状腺容积 影响因素 校正方法 

分 类 号：R153.2[医药卫生—营养与食品卫生学] R181.2[医药卫生—公共卫生与预防医学]