Application of transgenic mice to the molecular pathogenesis of cataract  

作　　者：Yue Zhang Xiao-Ya Chen Yu-Zhu Hu Xiao Zhang Shun-Fei Zheng Shan-Shan Hu 

机构地区：[1]Mudanjiang Medical University,Mudanjiang 157011,Heilongjiang Province,China [2]Department of Ophthalmology,Hongqi Hospital of Mudanjiang Medical University,Mudanjiang 157011,Heilongjiang Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第10期1929-1948,共20页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.82271070);the Heilongjiang Provincial Undergraduate Colleges and Universities Central to Support the Reform and Development of Local Colleges and Universities(No.2020YQ08);the Natural Science Foundation Project of Heilongjiang Province(Key Project/Outstanding Youth/Joint Guidance,No.LH2021H112);Doctoral Research Fund of Mudanjiang Medical University Affiliated Hongqi Hospital(No.2024-HQBS-03).

摘　　要：One of the most prevalent disorders that cause blindness worldwide is cataract,and its essence is the visual disorder caused by the opacity of the lens.The significant degree of variation in cataracts and the fact that a variety of factors can impact a patient’s lens transparency make it especially crucial to investigate the pathogenesis of cataracts at the molecular level.It has been found that more than 60 genes are linked to the formation of cataracts,and the construction of a transgenic mouse model of cataract similar to the selection of human lens clouding due to a variety of causes has become an important means of studying the pathogenesis of cataract.Therefore,the research on the application of transgenic mice to the molecular pathogenesis of cataracts will be the main topic of this review of the literature.

关 键 词：transgenic mice CATARACT LENS 

分 类 号：R776.1[医药卫生—眼科]