优化陈述性偏好研究的属性确定过程:基于优劣尺度法  

Optimizing the attribute selection process for stated preference study:a study based onbest-worst scaling

作　　者：陶颖 刘世蒙[1,2] 陈英耀 TAO Ying;LIU Shimeng;CHEN Yingyao(School of Public Health,Fudan University,Shanghai 200032,P.R.China;NHC Key Laboratory of Health Technology Assessment(Fudan University),Shanghai 200032,P.R.China)

机构地区：[1]复旦大学公共卫生学院,上海200032 [2]国家卫生健康委员会卫生技术评估重点实验室(复旦大学),上海200032

出　　处：《中国循证医学杂志》2024年第9期1079-1084,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金项目(编号:72074047)。

摘　　要：目的探究如何更加科学合理地确定陈述性偏好研究的属性。方法基于对象型优劣尺度法(BWS-1),利用平衡不完全区组设计生成BWS-1问卷,以2型糖尿病(T2DM)患者为研究对象,在海南和江苏省开展数据收集。采用模型法和计数法进行数据分析,获得各属性的优先级顺序。结果计数法和模型法的BWS-1结果具有较高的一致性,在11个属性中,影响T2DM患者二联药物选择偏好的前三位和后三位因素分别为血糖控制效果、心脑血管健康、低血糖风险;以及骨折、服药方式、服药频率。基于文献综述和定性研究,并结合BWS-1结果,本研究最终纳入陈述性偏好研究设计的属性为:血糖控制效果、低血糖风险、胃肠道不良反应风险、心脑血管健康、体重变化、服药方式及自付费用。结论BWS-1可以作为确定陈述性偏好研究如离散选择实验(DCE)属性的有效工具,但不建议仅依据BWS-1结果的优先级排序来确定陈述性偏好研究的属性范围,还需结合研究的政策目的及现实情况进行具体分析。Objective To explore how to determine the attributes of stated preference research more scientifically and reasonably.Methods Based on the best-worst scaling object case(BWS-1)method,a BWS-1 questionnaire was generated using a balanced incomplete block design.Data collection was conducted among type 2 diabetes mellitus(T2DM)patients in Hainan and Jiangsu provinces.Data analysis was performed using counting analysis and conditional logit model to obtain the priority order of each attribute.Results The results of BWS-1 using the counting and modelling approach showed high consistency.Among the 11 attributes,the top three attributes influencing the preference for second-line antihyperglycemic medications selection in T2DM patients were blood glucose control effectiveness,cardiovascular protection capability,and risk of hypoglycemic events,while the last three factors were dosing frequency,mode of administration and bone fracture.Based on literature review,qualitative research,and BWS-1 results,the seven attributes of discrete choice experiment and best-worst scaling profile case(BWS-2)were determined as follows:treatment efficacy,weight change,hypoglycemic events,gastrointestinal side effects,cardiovascular health,mode of administration and out-of-pocket cost.Conclusion BWS-1 can serve as an effective tool for determining the attributes of stated preference research.However,it is not recommended to solely rely on the priority ranking of BWS-1 results to determine the scope of attributes for stated preference research.It is necessary to conduct a specific analysis in conjunction with the research's policy objectives and real-world circumstances.

关 键 词：陈述性偏好 优劣尺度法 离散选择实验 属性选择 2型糖尿病 二联药物 

分 类 号：R-03[医药卫生]