载酶微球/聚乳酸复合纤维膜的制备及降解调控  

Preparation and degradation behavior of enzyme loaded microspheres/polylactic acid composite fiber membrane

作　　者：李静静 刘淑强[1] 刘明芳 李甫 张曼 贾潞 吴改红[1] 李诗雨 LI Jingjing;LIU Shuqiang;LIU Mingfang;LI Fu;ZHANG Man;JIA Lu;WU Gaihong;LI Shiyu(Taiyuan University of Technology,Jinzhong,030600,China)

机构地区：[1]太原理工大学,山西晋中030600

出　　处：《棉纺织技术》2024年第10期54-60,共7页Cotton Textile Technology

基　　金：山西省科技成果转化引导专项项目(202104021301053);山西省基础研究计划项目(20210302123114,202203021211146);山西省研究生实践创新项目(2023SJ084);山西省高校大学生创新创业训练计划项目(20220125);山西省艺术科学规划课题(22BG082)。

摘　　要：为了调控聚乳酸纤维膜降解周期,制备了载酶微球/聚乳酸复合纤维膜,对不同载酶微球含量的复合纤维膜进行降解试验并测试复合膜在降解过程中的表面形貌、力学性能、化学结构、黏均相对分子量以及质量损失情况。结果表明:随着降解时间的增加,复合纤维膜表面逐渐粗糙并发生纤维断裂;力学性能、质量以及黏均相对分子量均逐渐下降;制得的复合纤维膜能够实现在20周~32周的降解调控,其中,载酶微球质量分数为2.5%的纤维膜在20周时基本完全降解。认为:在脂肪酶的作用下,载酶微球/聚乳酸复合纤维膜的降解速度逐渐加快,拓宽了医用聚乳酸纤维膜的应用范围。In order to regulate the degradation cycle of polylactic acid fiber membrane,enzyme loaded microspheres/polylactic acid composite fiber membrane was prepared.The degradation tests were conducted and tested on the composite fiber membrane with different contents of enzyme loaded microsphere,the surface morphology,mechanical property,chemical structure,relative molecular weight of viscosity average and mass loss of the composite membrane during the degradation process.The results showed that with the increase of degradation time,the surface of the composite fiber membrane was gradually rough and fiber fracture occurred.Mechanical property,mass and relative molecular weight of viscosity were decreased gradually.The prepared composite fiber membrane could achieve degradation control in 20 weeks~32 weeks,in which the fiber membrane with the mass fraction of 2.5%enzyme microspheres was basically completely degraded in 20 weeks.It is concluded that the degradation rate of polylactic acid composite fiber membrane with enzyme-loaded microspheres is gradually accelerated under the action of lipase,which broadens the application range of medical polylactic acid fiber membrane.

关 键 词：聚乳酸纤维膜 脂肪酶 微球 同轴静电纺丝 降解调控 

分 类 号：TQ342.87[化学工程—化纤工业]