平分型糖链的结构与功能  

The structure and function of bisecting GlcNAc

作　　者：关锋 丰晶晶 卫玮 李想[2] 谭增琦 GUAN Feng;FENG Jingjing;WEI Wei;LI Xiang;TAN Zengqi(College of Life Sciences,Northwest University,Xi’an 710069,China;School of Medicine,Northwest University,Xi’an 710069,China)

机构地区：[1]西北大学生命科学学院,陕西西安710069 [2]西北大学医学院,陕西西安710069

出　　处：《西北大学学报（自然科学版）》2024年第5期840-846,共7页Journal of Northwest University（Natural Science Edition）

基　　金：国家自然科学基金(82172828,32071274)。

摘　　要：平分型N-乙酰氨基葡萄糖GlcNAc(Bisecting N-acetylglucosamine,bisecting GlcNAc)结构是指GlcNAc以β1,4-连接的方式连接到五糖核心的甘露糖(Man)上,是一种特殊的N糖基化修饰。平分型GlcNAc修饰参与多种生物过程,如细胞黏附、受精和胎儿发育、神经发生、免疫反应和肿瘤发展等。主要介绍平分型GlcNAc结构的形成过程,概述平分型GlcNAc修饰在神经系统、免疫反应、肿瘤发展和转移的生物学功能,并总结了解析平分型GlcNAc结构的技术进展,为相应生物学研究及药物开发提供科学参考。The bisecting N-acetylglucosamine(GlcNAc)structure,characterized byβ1,4-linked GlcNAc attached to the coreβ-mannose residue,represents a distinctive form of N-glycosylation modification.Bisecting GlcNAc modification is implicated in numerous biological processes such as cell adhesion,fertilization and embryonic development,neurogenesis,immune responses,and tumorigenesis.This review elucidates the formation mechanisms of bisecting GlcNAc structure and highlights its diverse biological functions in the nervous system,immune response,tumor metastasis and development.Furthermore,it provides an overview of the technological advances in analyzing bisecting GlcNAc structure,providing scientific references for corresponding biological research and drug development.

关 键 词：平分型N-乙酰氨基葡萄糖 MGAT3 N聚糖 质谱 

分 类 号：Q53[生物学—生物化学]