制药废水中头孢类抗生素残留检测方法探讨  

Exploration on Detection Methods for Cephalosporin Antibiotic Residues in Pharmaceutical Wastewater

作　　者：朱培颖 ZHU Peiying(Hangzhou Zhongmei Huadong Pharmaceutical Co.,Ltd.,Hangzhou,Zhejiang,310000,China)

机构地区：[1]杭州中美华东制药有限公司,浙江杭州310000

出　　处：《智能城市应用》2024年第10期73-75,共3页Smart City Application

摘　　要：较低检出限与较高灵敏度是LC-MS/MS法(液相色谱——两级串联质谱)的主要优势,加之对固相萃取进行前处理的相关工艺愈发成熟,因此现已广泛运用于检测地下水、再生水以及污水处理站中的出水含有的痕量抗生素。从当前相关领域的研究情况来看,制药废水中有关残留头孢类抗生素检测其所含浓度的成果相对有限,故而文本尝试建立并分析使用固相萃取——超高效液相色谱串联两级质谱法,检测制药厂产生的废水中头孢类抗生素的残留浓度。Low detection limit and high sensitivity are the main advantages of LC-MS/MS method(liquid chromatography-two-stage tandem mass spectrometry),coupled with the increasingly mature pre-treatment process for solid-phase extraction.Therefore,it has been widely used to detect trace antibiotics in groundwater,recycled water,and effluent from sewage treatment plants.From the current research situation in related fields,the results of detecting the concentration of residual cephalosporin antibiotics in pharmaceutical wastewater are relatively limited.Therefore,this article attempts to establish and analyze the use of solid-phase extraction ultra-high performance liquid chromatography tandem two-stage mass spectrometry to detect the residual concentration of cephalosporin antibiotics in pharmaceutical wastewater.

关 键 词：孢类抗生素 制药废水 抗生素残留 检测方法 

分 类 号：X703.1[环境科学与工程—环境工程]