西藏青中年人群睡眠与抑郁症状的相关性研究  

Association of sleep with depression of young and middle-aged people,Tibet

作　　者：何瑞峰[1] 尼玛曲措[1] 李亚杰[1] HE Rui-feng;NIMA Qu-cuo;LI Ya-jie(Tibet Center for Disease Control and Prevention,Lhasa,Tibet 850000,China)

机构地区：[1]西藏自治区疾病预防控制中心应急办,西藏拉萨850000

出　　处：《现代预防医学》2024年第18期3404-3409,共6页Modern Preventive Medicine

基　　金：国家重点研发计划(2017YFC0907302)。

摘　　要：目的 探讨西藏青中年人群睡眠时长、睡眠质量与抑郁症状之间的相关性。方法 在2018年5月至2019年8月,利用随机整群抽样方法抽取拉萨市城关区30岁~59岁人群开展问卷调查,采用多因素logistic回归模型分析睡眠与抑郁症状之间相关性。结果 本次研究纳入5 510名30~59岁青中年人,年龄为44.7±8.5岁,抑郁症状者占1.9%。多因素logistic回归模型显示,在控制潜在混杂因素后,睡眠时长过短、睡眠质量差是青中年抑郁症状的危险因素。与睡眠时长8h相比,眠时长≤6h和7h者抑郁症状的OR值(95%CI)分别为3.51(1.91~6.44)和1.89(1.06~3.37)。与睡眠质量好者相比,睡眠质量差者抑郁症状的OR值(95%CI)为2.24(1.46~3.46)。亚组分析显示,男性睡眠时长≤6h、女性睡眠时长≤7h是抑郁症状的危险因素;西藏青中年人群睡眠质量与发生抑郁症状的相关性,男女性别之间均有统计学意义。另外,青中年人群睡眠时长和睡眠质量两因素之间的联合效应与抑郁症状之间存在相关性,睡眠时长≤6h、睡眠质量差与抑郁症状的相关性最强(OR=7.43,95%CI:3.50~15.75)。结论 睡眠时长过短(≤7h)、睡眠质量差对西藏青中年人群抑郁症状患病风险有影响,同时存在联合效应。Objective To investigate the relationship of sleep duration and sleep quality with depression in young and middle-aged people in Tibet.Methods From May 2018 to August 2019,people aged 30 and above in Chengguan District of Lhasa City were selected by random cluster sampling method for questionnaire survey,and the independent and combined effects between sleep and depression was analyzed by multifactor logistic regression model.Results A total of 5 510 young and middle-aged people aged 30-59 years old were included in the study.The age was(44.7 ± 8.5) years old,and 1.9% of them were defined with depression.Multivariate logistic regression models showed that shorter sleep duration and poor sleep quality were risk factors for depression in young and middle-aged people after adjusting for confounding factors.Compared with 8 hours of sleep duration daily,the OR(95% CI) of depression for those with sleep duration ≤ 6h and 7h were 3.51(1.91-6.44) and 1.89(1.06-3.37),respectively.The OR(95% CI) of depression was 2.24(1.46-3.46) in the poor sleep quality group compared with those with good sleep quality.Subgroup analysis showed that male with sleep duration ≤6 h and female with sleep duration ≤7h were risk factors for depression.The association of sleep quality with depression was statistically significant in different gender groups.The combined effects of sleep duration and sleep quality were associated with depression,and sleep duration ≤6 h and poor sleep quality had the strongest association with depression(OR=7.43,95%CI:3.50-15.75).Conclusion Shorter sleep duration(≤7h) and poor sleep quality are associated with depression in young and middle-aged people at high altitude,and there is a combined effect.There are gender differences in the association of sleep duration with depression.

关 键 词：抑郁症状 睡眠时长 睡眠质量 青年人 中年人 

分 类 号：R749.4[医药卫生—神经病学与精神病学]