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作 者:胡振 张璐 周一夫 贺清明[2] 顾龙 张世旭[1] HU Zhen;ZHANG Lu;ZHOU Yifu;HE Qingming;GU Long;ZHANG Shixu(School of Nuclear Science and Technology,Lanzhou University,Lanzhou 730000,China;School of Nuclear Science and Technology,Xi'an Jiaotong University,Xi'an 710049,China)
机构地区:[1]兰州大学核科学与技术学院,兰州730000 [2]西安交通大学核科学与技术学院,西安710049
出 处:《核技术》2024年第9期53-61,共9页Nuclear Techniques
基 金:甘肃省科技计划(No.22ZD6FA050);国家重点研发计划(No.2020YFB1902101)资助。
摘 要:硼中子俘获治疗(Boron Neutron Capture Therapy,BNCT)是国际上极具应用前景的精准治癌手段,中子输运过程直接影响着束流特性和治疗计划的准确性。研究利用新型蒙特卡罗软件NECP-MCX(Nuclear Engineering Computational Physics)开展加速器驱动硼中子俘获治疗(Accelerator Based-Boron Neutron Capture Therapy,AB-BNCT)装置的中子输运过程,计算了中子输运过程中束流整形体出口处的束流参数及不同数据库下头模中的相对生物学剂量沉积。研究结果表明:在确定的束流整形器(Beam-Shaping Assembly,BSA)设计方案下,NECP-MCX模拟计算的中子束流参数结果与主流蒙特卡罗软件计算结果偏差微小,最大参数相对误差约6%,均符合国际原子能机构(International Atomic Energy Agency,IAEA)推荐值,证实NECP-MCX可用于ABBNCT中子输运模拟研究;针对Snyder头模,使用不同数据库与NECP-MCX相匹配,计算得到的头模内相对生物剂量参数均符合临床治疗标准,考虑到ENDF/B-VⅢ.0、JENDL-5更加全面细致,建议后续AB-BNCT治疗计划系统中计算数据库选择此两种数据库。[Background]Boron neutron capture therapy(BNCT)is a highly promising and precise cancer treatment technique with substantial application prospects worldwide.The neutron transport process directly influences beam characteristics and accuracy of treatment planning.[Purpose]This study aims to use the advanced Monte Carlo software,NECP-MCX,to investigate the neutron transport in an accelerator-driven BNCT(AB-BNCT)device.[Methods]The advanced Monte Carlo software,NECP-MCX,was used to investigate the neutron transport in an AB-BNCT device and calculate the beam parameters at the exit of the beam-shaping assembly(BSA),and results were compared with that calculated using the mainstream Monte Carlo software MCNP software.The relative biological dose deposition in Snyder head phantoms using various databases was calculated using both NECP-MCX and MCNP for comparative analysis.[Results and Conclusions]The results show that in the design of the designated beam-shaping assembly,the neutron beam parameters obtained from NECP-MCX simulations minimally deviated from those calculated using the mainstream Monte Carlo software.The values satisfy the specifications of the International Atomic Energy Agency,confirming the applicability of NECP-MCX for neutron transport simulation in AB-BNCT.Regarding the Snyder head phantom,the relative biological dose parameters obtained by matching NECP-MCX with different databases satisfy clinical treatment standards,providing a foundation for selecting databases in the biological-based treatment planning system.
关 键 词:NECP-MCX软件 硼中子俘获治疗 中子输运 相对生物学剂量沉积
分 类 号:TL99[核科学技术—核技术及应用] R730.55[医药卫生—肿瘤]
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