脂质代谢紊乱在糖尿病神经病变中作用的研究进展  

Progress in role of lipid metabolism disorders in diabetic neuropathy

作　　者：张燕忍 魏涛 吴艳青 ZHANG Yanren;WEI Tao;WU Yanqing(The Institute of Life Sciences,College of Life and Environmental Sciences,Wenzhou University,Wenzhou 325035,China)

机构地区：[1]温州大学生命与环境科学学院-生命科学研究院,温州325035

出　　处：《中国病理生理杂志》2024年第9期1727-1735,共9页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.82272254);浙江省自然科学基金资助项目(No.LY22H090007);温州市基础性科研项目(No.Y20220060);温州大学研究生科研创新基金资助项目(No.3162024004086)。

摘　　要：糖尿病神经病变是常见的糖尿病慢性并发症之一,具有高发病率和致残率等特点。糖尿病神经病变是由多种代谢失衡导致的结果,包括糖代谢和脂质代谢紊乱以及胰岛素缺乏或抵抗引起的胰岛素信号通路异常等。糖尿病神经病变发病机制与脂质代谢紊乱密切相关,脂质代谢紊乱,特别是脂肪酸,鞘脂和胆固醇等异常变化是导致糖尿病神经病变的重要因素及治疗的新靶点。本文综述了糖尿病环境下的脂质代谢紊乱对糖尿病神经病变发生发展的作用及机制,旨在为糖尿病神经病变治疗提供新的思路。Diabetic neuropathy is a common chronic complication of diabetes and is characterized by high incidence and disability rates.It is the result of various metabolic imbalances,including disorders of glucose metabolism,lipid metabolism,and insulin signaling abnormalities caused by insulin deficiency or resistance.The pathogenesis of diabetic neuropathy is closely related to lipid metabolism disorders.Disorders of lipid metabolism,especially abnormal changes in fatty acids,sphingolipids and cholesterol,are key causal factors and new therapeutic targets for diabetic neuropathy.This article reviews the disorder of lipid metabolism under diabetic conditions,and its role and mechanism in the occurrence and development of diabetic neuropathy,with the aim of providing new ideas for diabetic neuropathy treatment.

关 键 词：脂质代谢 糖尿病神经病变 脂肪酸 鞘脂 胆固醇 

分 类 号：R781.64[医药卫生—口腔医学] R589.2[医药卫生—临床医学] R363