铁死亡FSP1/CoQ_(10)信号轴在阿尔茨海默病中作用机制的研究进展  

Progress in mechanism of ferroptosis FSP1/CoQ_(10)signaling axis in Alzheimer disease

作　　者：赵炎 贺小平 张烨华 董贤慧 ZHAO Yan;HE Xiaoping;ZHANG Yehua;DONG Xianhui(Hebei University of Chinese Medicine,Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Dis-ease,Shijiazhuang 050091,China)

机构地区：[1]河北中医药大学,河北省心脑血管病中医药防治研究重点实验室,河北石家庄050091

出　　处：《中国病理生理杂志》2024年第9期1758-1763,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81803935);河北省自然科学基金资助项目(No.H2023423009);河北省科技计划(No.223777145D)。

摘　　要：铁死亡是一种以铁代谢失衡和脂质过氧化为特征的程序性细胞死亡方式。阿尔茨海默病(Alzheimer disease,AD)是一种神经退行性疾病。研究表明,铁死亡的脂质过氧化过程与AD的病理过程密切联系,其中铁死亡抑制蛋白1(ferroptosis suppressor protein 1,FSP1)/辅酶Q_(10)(coenzyme Q_(10),CoQ_(10))信号轴是铁死亡脂质过氧化过程中的关键调节因素。本文就FSP1/CoQ_(10)信号轴在AD中的作用机制进行综述,以期为AD的治疗提供参考。Ferroptosis is a form of programmed cell death characterized by iron metabolic imbalance and lipid peroxidation.Alzheimer disease(AD)is a neurodegenerative condition.Studies have shown that lipid peroxidation through ferroptosis plays a significant role in the progression of AD.Ferroptosis suppressor protein 1(FSP1)/coenzyme Q_(10)(CoQ_(10))signaling axis serves as a crucial regulatory element in the process of lipid peroxidation associated with ferroptosis.This review explores the mechanisms of the FSP1/CoQ_(10)signaling axis in AD,aiming to present a novel therapeutic approach for AD treatment.

关 键 词：铁死亡 FSP1/CoQ_(10)信号轴 阿尔茨海默病 脂质过氧化 

分 类 号：R742[医药卫生—神经病学与精神病学] Q255[医药卫生—临床医学] R363[生物学—细胞生物学]