视神经炎及相关神经系统特发性炎性脱髓鞘疾病的生物免疫治疗新进展  

Recent advances in the biological immunotherapy for optic neuritis and related idiopathic inflammatory demyelinating diseases of the nervous system

作　　者：段颖慧 薛群[1] DUAN Yinghui;XUE Qun(Department of Neurology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院神经内科,苏州215006

出　　处：《中国眼耳鼻喉科杂志》2024年第5期343-353,共11页Chinese Journal of Ophthalmology and Otorhinolaryngology

基　　金：国家自然科学基金面上项目(82371365);江苏省自然科学基金面上项目(BK20211075);苏州大学辰申协同创新中心(H230028)。

摘　　要：视神经炎(ON)泛指累及视神经的炎性病变,其中特发性视神经炎是主要的疾病类型。近年来,随着对该类疾病认识的逐渐加深,新的疾病类型被分列出来,命名发生了改变,相应的治疗也发生了改变。特别是生物靶向治疗已在近年正式走上舞台,部分生物制剂被相关指南推荐为一线治疗。本文就近年来生物制剂在ON,特别是特发性脱髓鞘性视神经炎中的规范应用和相关研究进展做总结介绍,为ON规范治疗提供参考。Optic neuritis(ON)is characterized by inflammatory lesions involving the optic nerve,with idiopathic optic neuritis being the main subtype.In recent years,a deeper understanding of idiopathic optic neuritis led to the identification of additional diseases corresponding changes in treatment approaches.Furthermore,biological immunotherapy has entered a new era,with some treatments recommended as first-line options according to relevant guidelines.This article introduces and summarizes the standardized application and progress of biological agents in ON,especially in idiopathic demyelinating optic neuritis,aiming to provide a reference for standardized treatment.

关 键 词：视神经炎 神经脱髓鞘疾病 生物免疫治疗 

分 类 号：R774.6[医药卫生—眼科]