胃癌组织中lncRNA PTPRG-AS1、miR-599表达与临床病理特征及预后的关系  

The relationship between the expression of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissue and clinical pathological characteristics and prognosis

作　　者：曹卉 谭婉燕 王晓林[1] 余愿 汪甜 CAO Hui;TAN Wanyan;WANG Xiaolin;YU Yuan;WANG Tian(Department of Gastroenterology,Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430077;Department of Gastroenterology,Union Hospital Tongji Medical College Huazhong University of Science and Technology;Department of Geriatrics,Xianning Central Hospital,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院消化内科,湖北武汉430077 [2]华中科技大学同济医学院附属协和医院消化内科 [3]咸宁市中心医院老年病科

出　　处：《胃肠病学和肝病学杂志》2024年第9期1121-1125,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：湖北省卫生健康委科研项目(WJ2021M248)。

摘　　要：目的分析胃癌组织中长链非编码RNA(long non-coding RNA,lncRNA)蛋白酪氨酸磷酸酶受体G基因反义链1(protein tyrosine phosphatase receptor G gene antisense chain 1,PTPRG-AS1)和miR-599表达水平,探讨其与临床病理特征及预后的关系。方法选取华中科技大学同济医学院附属梨园医院2016年1月至2020年2月收治的106例胃癌患者为研究对象。检测胃癌组织及瘤旁组织中lncRNA PTPRG-AS1和miR-599水平。结果胃癌组织中lncRNA PTPRG-AS1水平显著高于瘤旁组织,miR-599水平显著低于瘤旁组织(P<0.05)。lncRNA PTPRG-AS1与miR-599水平呈负相关(r=-0.485,P<0.05)。lncRNA PTPRG-AS1、miR-599均与TNM分期、浸润深度、分化程度、淋巴结转移相关(P<0.05)。lncRNA PTPRG-AS1低表达组、miR-599高表达组生存率显著升高(χ^(2)=8.206、6.881,P<0.05)。lncRNA PTPRG-AS1、miR-599表达是影响胃癌患者不良预后的危险因素(P<0.05)。结论胃癌组织中lncRNA PTPRG-AS1和miR-599表达水平与患者临床病理特征及预后密切相关。Objective To analyze the expression levels of long non-coding RNA(lncRNA)protein tyrosine phosphatase receptor G gene antisense chain 1(PTPRG-AS1)and miR-599 in gastric cancer tissues,and to explore their correlation with clinicopathological characteristics and prognosis.Methods A total of 106 gastric cancer patients admitted to Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology from Jan.2016 to Feb.2020 were collected as the research subjects.The levels of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissues and adjacent tissues were detected and compared.Results The expression level of lncRNA PTPRG-AS1 in gastric cancer tissue was obviously higher than that in adjacent tissues(P<0.05),the expression level of miR-599 was obviously lower than that in adjacent tissues(P<0.05).Pearson correlation analysis showed there was an obvious negative correlation between the expression levels of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissue(r=-0.485,P<0.05).lncRNA PTPRG-AS1 and miR-599 were both associated with TNM staging,depth of infiltration,degree of differentiation and lymph node metastasis(P<0.05).Survival was significantly higher in the lncRNA PTPRG-AS1 low expression group and miR-599 high expression group.LncRNA PTPRG-AS1 and miR-599 expression were risk factors for poor prognosis in gastric cancer patients(P<0.05).Conclusion The expression levels of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissues are closely related to the clinical pathological characteristics and prognosis of patients.

关 键 词：胃癌 长链非编码RNA 蛋白酪氨酸磷酸酶受体G基因反义链1 miR-599 临床病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]