溃疡性结肠炎患者心理状态及心理干预疗效的探究  

Psychological state and therapeutic effect of psychological intervention in ulcerative colitis patients

作　　者：崔旻[1] 边姗姗 刘苓[3] 姚萍[1] CUI Min;BIAN Shanshan;LIU Ling;YAO Ping(Department of Gastroenterology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000;Xinjiang Medical University;Department of Gastroenterology,West China Hospital,Sichuan University,China)

机构地区：[1]新疆医科大学第一附属医院消化科,新疆乌鲁木齐830000 [2]新疆医科大学 [3]四川大学华西医院消化内科

出　　处：《胃肠病学和肝病学杂志》2024年第9期1138-1143,共6页Chinese Journal of Gastroenterology and Hepatology

基　　金：四川省区域创新合作项目(2022YFQ0053)。

摘　　要：目的探究溃疡性结肠炎(ulcerative colitis,UC)疾病严重程度与焦虑、抑郁程度的相关性及心理干预对UC疗效的影响。方法选取在2022年1月至2023年1月就诊于新疆医科大学第一附属医院消化内科的117例确诊为UC的患者。采用简单临床结肠炎活动指数(simple clinical colitis activity index,SCCAI)和溃疡性结肠炎内镜下严重程度指数(ulcerative colitis endoscopic index of severity,UCEIS)对患者疾病严重程度进行评估,采用广泛性焦虑障碍量表(generalized anxiety disorder-7,GAD-7)和抑郁症筛查量表(patient health questionnaire-9,PHQ-9)对患者心理状态进行评估。分析UC疾病严重程度与焦虑、抑郁程度的相关性,并选取SCCAI评分为中重度组的患者,将患者随机分为两组,基础药物组给予UC基础药物治疗,心理干预组给予基础药物治疗联合心理干预治疗,共治疗20周,6个月后评估心理干预对UC疗效的影响。结果Spearman相关性分析显示,UCEIS评分与SCCAI评分之间存在相关性(r=0.665,P<0.01)。UC患者普遍存在焦虑、抑郁等心理状态,且随着疾病严重程度的增加,焦虑、抑郁程度也随之增加。两组患者治疗前后症状评分及焦虑评分均有所改善,心理干预组较基础治疗组症状评分改善更明显(t=3.512,P<0.05;t=2.154,P<0.05);基础治疗组治疗后焦虑评分较治疗前有所改善(t=2.898,P<0.05),抑郁评分治疗前后无明显差异(t=1.463,P>0.05);心理干预组在治疗后焦虑及抑郁评分均有所下降(t=5.919,P<0.05;t=3.197,P<0.05)。结论随着UC疾病严重程度的加重,患者焦虑、抑郁程度也随之加重。在基础治疗的基础上联合心理干预治疗,能更好地改善UC患者临床症状,并且可以缓解患者焦虑、抑郁状态。Objective To investigate the correlation between the severity of ulcerative colitis(UC)illness and the extent of their anxiety and depression,and the influence of mental intervention on the outcomes of UC.[WTHZ]Methods One hundred and seventeen patients diagnosed with UC who visited the Department of Gastroenterology,the the First Affiliated Hospital of Xinjiang Medical University from Jan.2022 to Jan.2023 were selected.Simple clinical colitis activity index(SCCAI)and ulcerative colitis endoscopic index of severity(UCEIS)were used to assess the disease severity of patients.The generalized anxiety disorder-7(GAD-7)and patient health questionnaire-9(PHQ-9)were used to assess the patients′psychological status.The correlation between the severity of UC disease and the degree of anxiety and depression was analyzed.Patients with SCCAI score of moderate to severe group were selected,and the patients were randomized grouped into UC foundation treatment(foundation treatment group)and combination of foundation treatment with mental intervention treatment(mental intervention group),then evaluated the effect of psychological intervention on UC.[WTHZ]Results Spearman correlation analysis showed that there was a correlation between UCEIS scores and SCCAI scores(r=0.665,P<0.01).Anxiety and depression were common in UC patients,and the degree of anxiety and depression increased with the severity of the disease.Symptom scores and anxiety score improved in both groups before and after the intervention,with more significant improvement in the mental intervention group than in the foundation treatment group(t=3.512,P<0.05;t=2.154,P<0.05).The anxiety score was reduced after treatment in the foundation treatment group(t=2.898,P<0.05).There was no significant difference in depression score before and after treatment in the foundation treatment group(t=1.463,P>0.05).There was a reduction in both anxiety and depression score after the treatment in the mental intervention group(t=5.919,P<0.05;t=3.197,P<0.05).[WTHZ]Conclusion As the seve

关 键 词：溃疡性结肠炎 焦虑 抑郁 心理干预 疾病活动度 

分 类 号：R574.62[医药卫生—消化系统]