二肽基肽酶-4抑制剂在缺血性卒中预防和治疗中的作用  

Role of dipeptidyl peptidase-4 inhibitors in the prevention and treatment of ischemic stroke

作　　者：张菁轩 何轩 沙杜鹃 Zhang Jingxuan;He Xuan;Sha Dujuan(Department of General Medicine,Drum Tower Hospital,Clinical College of Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of General Medicine,the Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China)

机构地区：[1]南京中医药大学鼓楼临床医学院全科医学科,南京210008 [2]南京大学医学院附属鼓楼医院全科医学科,南京210008

出　　处：《国际脑血管病杂志》2024年第5期369-373,共5页International Journal of Cerebrovascular Diseases

基　　金：南京市医学科技发展重点项目(ZKX 21025)。

摘　　要：糖尿病是缺血性卒中的重要危险因素,而缺血性卒中后的应激性高血糖会加剧缺血性脑损伤。二肽基肽酶-4(dipeptidyl peptidase-4,DPP-4)抑制剂作为近年来新开发的降糖药,成为2型糖尿病治疗药物的重要研究方向之一。虽然现有的临床试验数据尚未明确证实DPP-4抑制剂在预防糖尿病患者缺血性卒中方面的有效性,但动物模型研究显示DPP-4抑制剂能通过抗炎、抗凋亡以及促进神经发生和血管新生等机制,在缺血性脑损伤过程中发挥保护作用。文章综述了DPP-4抑制剂在缺血性卒中预防和治疗中的作用及其可能机制。Diabetes is an important risk factor for ischemic stroke,and stress hyperglycemia after ischemic stroke will aggravate ischemic brain damage.Dipeptidyl peptidase-4(DPP-4)inhibitors,as newly developed hypoglycemic drugs in recent years,have become one of the important research directions of type 2 diabetes drugs.Although the existing clinical trial data have not clearly confirmed the effectiveness of DPP-4 inhibitors in preventing ischemic stroke in patients with diabetes,animal model studies have shown that DPP-4 inhibitors can exert protective effects during ischemic brain injury through mechanisms such as anti-inflammatory,anti-apoptotic and promoting neurogenesis and angiogenesis.This article reviews the role and possible mechanisms of DPP-4 inhibitors in the prevention and treatment of ischemic stroke.

关 键 词：卒中 脑缺血 二肽基肽酶4 二肽基肽酶Ⅳ抑制剂 糖尿病 2型 神经保护药 

分 类 号：R743.3[医药卫生—神经病学与精神病学]