丁苯酞注射联合依达拉奉对急性脑梗死患者凝血及脑血管储备功能的影响  

Effects of Butylphthalide Injection Combined with Edaravone on Coagulation and Cerebrovascular Reserve Function in Patients with ACI

作　　者：刘志鹏 张帅娜 耿艳涛 王伟霞 LIU Zhi-peng;ZHANG Shuai-na;GENG Yan-tao;WANG Wei-xia(Emergency Department,Kaifeng 155th Hospital,Kaifeng 475000,Henan Province,China;Intensive Care Unit,Kaifeng Second Chinese Medicine Hospital,Kaifeng 475004,Henan Province,China)

机构地区：[1]开封一五五医院急诊科,河南开封475000 [2]河南省开封市第二中医院重症ICU,河南开封475004

出　　处：《罕少疾病杂志》2024年第9期18-19,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的 探讨丁苯酞(NBP)注射联合依达拉奉对急性脑梗死(ACI)患者凝血及脑血管储备(CVR)功能的影响。方法 选取2021年05月-2022年05月在我院就诊的98例ACI患者,按照随机信封法分为2组,对照组(n=47,常规治疗+依达拉奉),观察组(n=51,常规治疗+依达拉奉+NBP),2组均治疗14d,对比两组患者治疗效果、氧化应激、凝血功能与CVR功能。结果 观察组治疗总有效率较对照组高(P<0.05);观察组治疗后谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平大于对照组(P<0.05);观察组治疗后活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)较对照组长(P<0.05);治疗后观察组CVR能力高于对照组(P<0.05)。结论 NBP注射联合依达拉奉治疗ACI患者疗效较好,且能改善患者凝血功能,降低氧化应激反应,提升CVR功能。Objective To explore the effects of NBP and edaravone on coagulation and CVR function in patients with ACI.Methods 98 patients with ACI treated in the hospital from May 2021 to May 2022 were selected and divided into control group(n=47,routine treatment+edaravone)and observation group(n=51,routine treatment+edaravone+NBP)by the random envelope method.Both groups were treated for 14 days.Treatment effect,oxidative stress,coagulation function and CVR function were compared.Results Total effective rate of treatment and levels of GSH-Px and SOD in observation group were higher than those in control group(P<0.05).APTT and PT in observation group after treatment were longer than those in control group(P<0.05).After treatment,CVR ability was higher in observation group compared to control group(P<0.05).Conclusion NBP with edaravone has a good efficacy on ACI.It can improve coagulation function,reduce oxidative stress response,and enhance CVR ability.

关 键 词：丁苯酞 依达拉奉 急性脑梗死 凝血 脑血管储备功能 

分 类 号：R[医药卫生]