影响肺癌化疗患者发生肺部感染的危险因素分析  

Analysis of Risk Factors Affecting Lung Infection in Patients with Lung Cancer Chemotherapy

作　　者：张小曼 张伟华[1] 房翠 ZHANG Xiao-man;ZHANG Wei-hua;FANG Cui(Shangqiu First People's Hospital,Shangqiu 476100,Henan Province,China;Hebei Medical University,Shijiazhuang 050011,Hebei Province,China)

机构地区：[1]商丘市第一人民医院,河南商丘476100 [2]河北医科大学,河北石家庄050011

出　　处：《罕少疾病杂志》2024年第9期42-44,共3页Journal of Rare and Uncommon Diseases

基　　金：国家自然科学基金面上项目(81871749);河南省医学科技攻关计划(联合共建)项目(LHGJ20191501)。

摘　　要：目的 分析影响肺癌化疗患者发生肺部感染的危险因素。方法 选取我院2022年8月至2023年7月期间收治的60例肺癌化疗患者进行研究。根据是否发生肺部感染分为感染组12例与未感染组48例。回归性分析两组患者临床资料,分析肺部感染的高危因素,并提出相对应干预措施。结果 两组在性别、饮酒史、高血压史、肺癌类型上差异无意义,P>0.05;在年龄、吸烟史、糖尿病史、TNM分期、治疗方案、化疗药物、化疗周期、KPS评分、白蛋白、肝素结合蛋白、PCT、IL-6、s TREM-1、SP-D、PTX3、抑郁评分指数上存在差异,P<0.05。年龄≥60岁、TNM分期Ⅲ-Ⅳ期、多种化疗药物联合、化疗周期≥4周、KPS评分<80分、白蛋白<30g/L、肝素结合蛋白≥35 ng/m L、PCT≥1.2ng/m L、IL-6≥38pg/m L、s TREM-1≥26 ng/m L、SP-D≥0.5 pg/m L、PTX3≥209 pg/m L、抑郁评分指数60%-69%为肺癌化疗患者发生肺部感染的独立危险因素(P<0.05)。结论 肺癌化疗患者发生肺部感染危险因素有高龄、吸烟、糖尿病等,且与一些生物标志物指标相关,并且患者的情绪对病情的变化有一定的微妙联系,临床需要针对存在高危因素患者进行干预,消除或控制高危因素,降低肺部感染风险。Objective To analyze the risk factors of lung infection in patients with lung cancer chemotherapy.Methods 60 patients with lung cancer treated with chemotherapy in our hospital from August 2022 to July 2023 were selected for study.According to the occurrence of pulmonary infection,patients were divided into infected group(12 cases)and uninfected group(48 cases).The clinical data of the two groups were analyzed by regression,the risk factors of pulmonary infection were analyzed,and the corresponding intervention measures were proposed.Results There was no significant difference in sex,drinking history,hypertension history and lung cancer type between the two groups(P<0.05).There were differences in age,smoking history,diabetes history,TNM stage,treatment regimen,chemotherapy drugs,chemotherapy cycle,KPS score,albumin,heparin binding protein,PCT,IL-6,sTREM-1,SPD,PTX3 and depression score index(P<0.05).Age≥60 years,TNM stageⅢtoⅣ,combination of multiple chemotherapy drugs,chemotherapy cycle≥4 weeks,KPS score<80 points,albumin<30g/L,heparin-binding protein≥35 ng/mL,PCT≥1.2ng/mL,IL-6≥38pg/mL,sTREM-1≥26 ng/mL,SP-D≥0.5pg/mL,PTX3≥209 pg/mL and depression score index 60%-69%were independent risk factors for pulmonary infection in patients with lung cancer chemotherapy(P<0.05).Conclusion The risk factors for pulmonary infection in patients with lung cancer chemotherapy include old age,smoking,diabetes,etc.,which are related to some biomarkers,and the mood of patients has a subtle relationship with the change of the disease.Clinical intervention is necessary for patients with high-risk factors to eliminate or control the high-risk factors and reduce the risk of lung infection.

关 键 词：肺癌 化疗 肺部感染 危险因素 应对措施 

分 类 号：R734.2[医药卫生—肿瘤]