血清CEA、TK1、CA724、PGⅠ/PGⅡ联合检验在早期胃癌中的诊断效能  

Diagnostic Efficacy of Serum CEA,TK1,CA724,PG I/PG II Combined Test in Early Gastric Cancer

作　　者：郑佳欣 ZHENG Jia-xin(Blood Transfusion Department,Jiaozuo People's Hospital,Jiaozuo 454001,Henan Province,China)

机构地区：[1]焦作市人民医院输血科,河南焦作454001

出　　处：《罕少疾病杂志》2024年第9期88-90,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 分析血清癌胚抗原(CEA)、胸苷激酶(TK1)、糖类抗原(CA)724、胃蛋白酶原I(PGI)/PGⅡ联合检测诊断早期胃癌的效果。方法 将2021年8月-2022年8月本院收治的89例早期胃癌患者纳入观察组;另将同期本院收治的90例胃良性病变患者纳入对照组;并将同期于本院行健康体检的85例健康人群纳入健康组,采集三组静脉血,检测对比其血清CEA、TK1、CA724、PGⅠ/PGⅡ的差异;另绘制受试者工作曲线(ROC),分析CEA、TK1、CA724、PGⅠ/PGⅡ联合检测诊断早期胃癌的效能。结果 观察组CEA为(19.84±2.23)ng/m L、TK1为(3.97±0.52)pmol/L、CA724为(42.89±5.31)U/m L,高于对照组的(2.57±0.26)ng/m L、(1.18±0.23)pmol/L、(4.15±0.57)U/m L与健康组的(2.36±0.35)ng/m L、(1.16±0.27)pmol/L、(3.87±0.46)U/m L,PGⅠ/PGⅡ为(2.31±0.26),低于对照组的(4.89±0.75)与健康组的(5.31±0.96),差异有统计学意义(P<0.05);ROC结果显示:CEA、TK1、CA724、PGⅠ/PGⅡ联合检测诊断早期胃癌的曲线下面积(AUC)为0.947(95%CI:0.910-0.984),高于几者单独检测的0.846(95%CI:0.787-0.904)、0.862(95%CI:0.801-0.922)、0.867(95%CI:0.814-0.919)、0.873(95%CI:0.819-0.928)。结论 早期胃癌患者机体内的CEA、TK1、CA724呈异常高表达,PGⅠ/PGⅡ呈异常低表达,四者联合可有效提高早期胃癌的诊断准确度,为临床提供可靠的依据,临床应用价值较高,值得大力推行。Objective To analyze the effectiveness of combined detection of serum carcinoembryonic antigen(CEA),thymidine kinase(TK1),carbohydrate antigen(CA)724,and pepsinogen I(PGI)/PGII in the diagnosis of early gastric cancer.Methods 89 patients with early gastric cancer admitted to our hospital from August 2021 to August 2022 were included in the observation group;in addition,90 patients with benign gastric lesions admitted to our hospital during the same period were included in the control group;85 healthy people who underwent health examination in our hospital at the same time were included in the healthy group.Venous blood was collected from three groups,and the differences of serum CEA,TK1,CA724,PG I/PG II were detected and compared;additionally,draw a receiver operating curve(ROC)to analyze the efficacy of CEA,TK1,CA724,and PG I/PG II combined detection in the diagnosis of early gastric cancer.Results The CEA of the observation group was(19.84±2.23)ng/mL,TK1 was(3.97±0.52)pmol/L,and CA724 was(42.89±5.31)U/mL,which was higher than the control group's(2.57±0.26)ng/mL,(1.18±0.23)pmol/L,and(4.15±0.57)U/mL,and the healthy group's(2.36±0.35)ng/mL,(1.16±0.27)pmol/L,and(3.87±0.46)U/mL,with PG I/PG II being(2.31±0.26)and lower than the control group's(4.89±0.75).Compared to the healthy group(5.31±0.96),the difference was statistically significant(P<0.05);the ROC results showed that the area under the curve(AUC)for the combined detection of CEA,TK1,CA724,and PG I/PG II in the diagnosis of early gastric cancer was 0.947(95%CI:0.910-0.984),which was higher than the individual detection of 0.846(95%CI:0.787-0.904),0.862(95%CI:0.801-0.922),0.867(95%CI:0.814-0.919),and 0.873(95%CI:0.819-0.928).Conclusion The expression of CEA,TK1,and CA724 in early gastric cancer patients is abnormally high,while the expression of PGI/PGII is abnormally low.The combination of the four can effectively improve the diagnostic accuracy of early gastric cancer,provide reliable basis for clinical practice,and have high clinical application

关 键 词：早期胃癌 癌胚抗原 胸苷激酶 诊断效能 受试者工作曲线 曲线下面积 

分 类 号：R735.2[医药卫生—肿瘤]