血清CD64、PCT水平预测急性髓细胞白血病化疗继发感染的临床价值  

The Clinical Value of Serum CD64 and PCT Levels to Predict the Secondary Infection of Chemotherapy for AML

作　　者：许沛 XU Pei(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)

机构地区：[1]河南科技大学第一附属医院,河南洛阳471000

出　　处：《罕少疾病杂志》2024年第9期126-128,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探讨血清外周血中性粒细胞CD64、降钙素原(PCT)预测急性髓细胞白血病(AML)化疗后继发感染的临床价值。方法 回顾性分析我院2020年6月至2022年6月收治的126例AML患者,统计所有AML患者化疗后继发感染情况,记录患者入院时年龄、性别等临床资料及血清CD64、PCT水平,采用回归分析AML患者化疗后继发感染发生的危险因素,并采用受试者工作特 征曲线(ROC)评价血清CD64、PCT对AML患者化疗后继发感染的预测价值。结果 126例AML患者化疗后,共有78例出现继发感染(感染组),发生率为6190%,其余48例患者未感染(未感染组)。两组年龄、化疗阶段及血清CD64、PCT水平比较有统计学意义(P<005)。经Logstc回归分析显示,年龄、化疗阶段、血清CD64及PCT均是引起AML患者化疗继发感染发生的危险因素(P<005)。经ROC曲线分析得出,血清CD64、PCT单项预测AML患者化疗后继发感染的AUC分别为0806、0733,灵敏度分别为7732%、7819%,特异度分别为7927%、7224%,两者联合预测AML患者化疗继发感染的AUC为0895,灵敏度为8845%,特异度为8027%,均高于两者单独预测。结论 疗后继发感染与年龄、化疗阶段、血清CD64及PCT等多种因素有关,早期检测血清CD64、PCT能较好的预测AML患者化疗后继发感染发生风险。Objective To investigate the clinical value of serum peripheral neutrophilic cells CD64 and procalcitonin(PCT)in predicting secondary infection following chemotherapy in acute myeloid leukemia(AML).Methods 126 AML patients admitted to our hospital from June 2020 to June 2022,analyzed the secondary infection of all AML patients after chemotherapy,recorded clinical data such as age and gender and serum CD64 and PCT level,used regression to analyze the risk factors of secondary infection after chemotherapy in AML patients,and used the receiver working characteristic curve(ROC)to evaluate serum CD64 and PCT for the predictive value of secondary infection after chemotherapy in AML patients.Results A total of 126 AML patients had secondary infection(infected group),with an incidence of 61.90%,while the remaining 48 patients were uninfected(uninfected group).Age,chemotherapy stage and serum CD64 and PCT levels were statistically significant between the two groups(P<0.05).By Logistic regression analysis,age,chemotherapy stage,serum CD64 and PCT were all risk factors for secondary infection of chemotherapy in AML patients(P<0.05).According to the ROC curve analysis,the AUC of serum CD64 and PCT predicting secondary infection after chemotherapy in AML patients were 0.806 and 0.733,respectively,and the sensitivity was 77.32%and 78.19%,respectively,79.27%and 72.24%.The combination of the AUC predicting secondary infection with chemotherapy in AML patients was 0.895,88.45%sensitivity and 80.27%specificity,which were higher than those predicted separately.Conclusion Secondary infection in AML patients after chemotherapy is related to various factors such as age,chemotherapy stage,serum CD64 and PCT,and early detection of serum CD64 and PCT can better predict the risk of secondary infection in AML patients after chemotherapy.

关 键 词：外周血中性粒细胞CD64 降钙素原 急性髓细胞白血病 化疗 继发感染 

分 类 号：R733.7[医药卫生—肿瘤]