400例过敏性疾病患儿血清特异性IgE检测过敏原结果构成研究  

Study on the Results of Serum Specific IgE Detection for Allergens in 400 Children with Allergic Diseases

作　　者：李娟 胡广成 陈欢欢 王昕 曹焕珍[1] LI Juan;HU Guang-cheng;CHEN Huan-huan;WANG Xin;CAO Huan-zhen(Department of Pediatrics,Yellow River Sanmenxia Hospital,Sanmenxi 472000,Henan Province,China)

机构地区：[1]黄河三门峡医院儿科,河南三门峡472000

出　　处：《罕少疾病杂志》2024年第9期142-144,共3页Journal of Rare and Uncommon Diseases

基　　金：中国水利水电第十一工程有限公司科技项目(2021-217)。

摘　　要：目的 调查400例过敏性疾病患儿血清特异性Ig E(s Ig E)检测过敏原结果构成及分布特点,为医护人员开展疾病防控管理提供参考。方法 选取2020年1月~2021年4月就诊于本院的400例过敏性疾病患儿为研究对象,采用免疫印迹方法检测患儿血清中总Ig E和特异性Ig E抗体水平。结果 400例过敏性疾病患儿中血清总Ig E阳性率为65.00%(260/400),s Ig E阳性率为65.75%(263/400)。其中吸入性过敏原阳性率排名首位是艾蒿(22.25%),其次为屋尘螨/粉尘螨(15.25%)、猫毛(10.25%)、点青霉/烟曲霉(9.25%)、榆树(8.50%);食入性过敏原阳性率排名首位是为小麦(12.75%),其次分别是牛奶(8.25%)、坚果组合(6.00%)、蟹(5.00%)、虾(4.50%)。性别分布:男性患儿s Ig E阳性、牛奶过敏原阳性率高于女性患儿(P<0.05);年龄分布:随患儿年龄增长,食入性过敏原阳性率呈递减趋势,吸入性过敏原阳性率呈递增趋势;疾病分布:不同疾病牛奶、狗毛皮屑、屋尘螨/粉尘螨过敏阳性率对比,差异有统计学意义(P<0.05)。结论 艾蒿、屋尘螨/粉尘螨、小麦等是过敏性疾病患儿常见过敏原,且不同年龄、不同性别、不同疾病过敏原阳性率存在差异,为本地儿童过敏性疾病防控工作提供参考。Objective To investigate the composition and distribution of serum specific IgE(sIgE)in 400 children with allergic diseases,and to provide reference for medical staff to carry out disease prevention and control.Methods 400 children with allergic diseases admitted to our hospital from January 2020-April 2021 were selected as the study objects,and the serum total IgE and specific IgE antibody levels were detected by western blot method.Results The positive rate of total IgE and SiGe was 65.00%(260/400)and 65.75%(263/400),respectively.The positive rate of inhaled allergens ranked first with mugwort(22.25%),followed by house dust mite/dermatophagoides farinae(15.25%),cat hair(10.25%),Penicillium punctatum/Aspergillus fumigatus(9.25%)and Ulmus pumila(8.50%).The positive rate of food allergens ranked first in wheat(12.75%),followed by milk(8.25%),nut combination(6.00%),crab(5.00%)and shrimp(4.50%).Gender distribution:The positive rate of sIgE and milk allergen in male children was higher than that in female children(P<0.05).Age distribution:With the increase of age,the positive rate of ingestion allergens showed a decreasing trend,while the positive rate of inhalation allergens showed an increasing trend.Disease distribution:The positive rates of milk,dog dander,house dust mite/dust mite allergy were compared in different diseases,and the difference was statistically significant(P<0.05).Conclusion Milk,egg white,house dust mite/dust mite are common allergens in children with allergic diseases,and the positive rates of allergens are different in different ages,genders and diseases,providing reference for the prevention and control of allergic diseases in local children.

关 键 词：过敏性疾病 SIGE 过敏原 总IGE 

分 类 号：R781.67[医药卫生—口腔医学]