血清HbA1c,Hcy水平对帕金森病患者认知功能障碍的预测价值  

The predictive value of the relationship between serum HbA1c,Hcy levels and cognitive impairment in Parkinson's disease patients

作　　者：王艳姣 林燕 张爱华 WANG Yan-jiao;LIN Yan;ZHANG Ai-hua(Health Management Department of Tai'an 88 Hospital,Shandong Tai'an 271000)

机构地区：[1]泰安八十八医院健康管理部,山东泰安271000 [2]泰安八十八医院神经内科,山东泰安271000

出　　处：《医学检验与临床》2024年第8期15-19,共5页Medical Laboratory Science and Clinics

摘　　要：目的:探究血清HbA1c、Hcy水平与帕金森病患者(Parkinson's disease,PD)认知功能障碍的关系并探讨其对PD患者认知功能障碍的预测价值。方法:选择2020年1月-2022年6月来泰安八十八医院治疗帕金森病的100例患者为研究对象,根据有无发生认知功能障碍分为认知功能障碍组56例和认知功能正常组44例,并选取同期100例体检健康者为对照组。检测患者血清糖化血红蛋白(HbA1c)、同型半胱氨酸(Hcy)水平、蒙特利尔认知评估(MocA);采用Pearson法分析PD认知功能障碍患者血清HbA1c,Hcy水平与MoCA评分的相关性;采用受试者工作特征曲线(ROC曲线)分析血清HbA1c、Hcy水平对PD患者认知功能障碍的预测价值。结果:PD组患者血清HbA1c、MocA评分低于对照组,Hcy水平高于对照组,差异有统计学意义(P<0.001);认知功能正常组HbA1c、Hcy水平及MocA评分高于对照组,差异有统计学意义(P<0.001);Spearman相关性分析显示,HbAlc水平与MocA评分呈正相关,Hcy水平与MocA评分呈负相关,差异有统计学意义(P<0.05);ROC曲线分析显示,血清HbA1c,Hcy水平单独与联合均对PD患者预后有一定诊断价值(AUC>0.001,P<0.001),血清HbA1c联合Hcy水平预测PD患者预后的曲线下面积为0.841(95%CI-0.766-0.916,P<0.001),灵敏度为72.20%,特异度为87.00%,高于两者单独预测的曲线下面积(P<0.001)。结论:PD患者血清HbAlc、Hcy水平降低,并发认知功能障碍时二者水平进一步降低,两者对认知功能障碍有一定预测价值。Objective:To investigate the relationship between serum HbA1c and Hcy levels and cognitive dysfunction in Parkinson's disease(PD)patients and to explore their predictive value for cognitive dysfunction in PD patients.Methods:A total of 100 patients with Parkinson's disease who came to Tai'an 88 Hospital for treatment from January 2020 to June 2022 were selected as the research subjects,and were divided into 56 cases in the cognitive impairment group and 44 cases in the normal cognitive function group according to whether there was cognitive impairment,and 1o0 healthy patients in the same period were selected as the control group.The serum glycosylated hemoglobin(HbAic),homocysteine(Hcy)and Montreal Cognitive Assessment(MocA)were measured,the correlation between serum HbA1c and Hcy levels and MoCA score in patients with PD cognitive dysfunction was analyzed by Pearson method,and the predictive value of serum HbA1c and Hcy levels on cognitive dysfunction in PD patients was analyzed by receiver operating characteristic curve(ROC curve).Results:The results showed that the serum HbA1c and MocA scores of patients in the PD group were lower than those in the control group,and the Hcy levels were higher than those in the control group,with statistical significance(P<0.001);The HbA1c,Hcy levels,and MocA scores in the group with normal cognitive function were higher than those in the control group,with statistically significant differences(P<0.001);Spearman correlation analysis showed that HbAlc level was positively correlated with MocA score,while Hcy level was negatively correlated with MocA score,with a statistically significant difference(P<0.05);Receiver operating characteristic analysis showed that serum HbA1c and Hcy levels alone and in combination had certain diagnostic value for the prognosis of PD patients(AUC>0.001,P<0.001):The area under the curve of serum HbA1c combined with Hcy levels to predict the prognosis of PD patients was 0.841(95%CI-0.766-0.916,P<0.001),the sensitivity was 72.20%,and the specificity wa

关 键 词：HBA1C HCY 帕金森病 认知功能障碍 预测价值 

分 类 号：R742.5[医药卫生—神经病学与精神病学]