离子色谱-质谱联用技术在生命健康领域中的应用进展  

Advances in the application of ion chromatography-mass spectrometry in the fields of life and health

作　　者：易雨欣 金米聪[1] YI Yuxin;JIN Micong(Ningbo Municipal Center for Disease Control and Prevention,Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang Province,Ningbo 315010,China)

机构地区：[1]宁波市疾病预防控制中心,浙江省微量有毒化学物健康风险评估技术研究重点实验室,浙江宁波315010

出　　处：《色谱》2024年第10期923-934,共12页Chinese Journal of Chromatography

基　　金：宁波市公益研究重点科技计划项目(2021S102);国家自然科学基金项目(22176175).

摘　　要：离子色谱是一种用于分离强极性和可电离物质的色谱技术,质谱是一种基于离子m/z的分析技术,离子色谱与质谱联用(IC-MS)可用于复杂样品中可电离化合物(包括无机化合物和有机化合物)的分离、鉴定与定量。本文综述了IC-MS技术的发展以及近20年来IC-MS技术在食品分析、药物分析、代谢组学和临床中毒检测等领域的应用进展和未来发展趋势。在食品分析方面,本文主要介绍了IC-MS技术在无机阴离子、有机酸、极性农药、生物胺和糖类等物质检测方面的应用进展;在药物分析方面,本文主要介绍了IC-MS技术在药物杂质分析、药物降解产物鉴定和血药浓度测定领域的研究进展;在代谢组学方面,本文主要介绍了IC-MS技术在生物基质中的有机酸、糖磷酸酯、核苷酸等强极性代谢物分离、分析领域的研究进展;在临床中毒分析方面,本文主要介绍了IC-MS技术在烷基甲基膦酸、甲基膦酸、草甘膦、3-硝基丙酸和茚满二酮类鼠药等强极性或可电离有毒化合物检测方面的应用进展。本文将为IC-MS技术在生命健康领域的进一步拓展和应用提供有益参考。Ion chromatography is a technique commonly used to separate strongly polar and ionizable substances;it can be used to separate,identify,and quantify ionizable compounds in complex samples when coupled with mass spectrometry,and is currently being used in the application of food analysis,drug analysis,metabolomics and clinical poisoning analysis.Herein,we review the development of ion chromatography-mass spectrometry(IC-MS),its progress over the past 20 years,and future trends in the abovementioned areas.The IC-MS research progress and applications for the determination of inorganic anions,organic acids,polar pesticides,biogenic amines,and sugars in the food field are discussed.Drug analysis applications are discussed mainly in relation to the analysis of drug impurities,identifying drug degradation products,and determination of plasma concentration,while the separation and analysis of strongly polar metabolites,such as organic acids,sugar phosphates,and nucleotides in biological matrices are discussed in relation to metabolomics.Advances in the analysis of strongly polar or ionizable toxic compounds,such as alkyl methylphosphonic acid,methylphosphonic acid,glyphosate,3-nitropropionic acid,and indandione rodenticides,are mainly discussed in clinical poisoning analysis field.This paper is expected to become a useful reference for the further expansion and application of IC-MS in the life and health fields.

关 键 词：离子色谱-质谱联用 食品分析 药物分析 代谢组学 临床中毒分析 综述 

分 类 号：O658[理学—分析化学]