血清TSH、sTg表达与甲状腺乳头状癌患者超声引导下射频消融预后的关系研究  

Relationship between serum TSH,sTg and prognosis of ultrasound-guided radiofrequency ablation in patients with papillary thyroid cancer

作　　者：孟芳 沈玉琴 MENG Fang;SHEN Yuqin(Ultrasound Department of Hengshui Second People's Hospital,engshui,Hebei053000,China)

机构地区：[1]河北省衡水市第二人民医院超声科,河北衡水053000

出　　处：《中国实验诊断学》2024年第9期1026-1029,共4页Chinese Journal of Laboratory Diagnosis

基　　金：衡水市科技计划项目(2022014087Z)。

摘　　要：目的观察血清刺激性甲状腺球蛋白(sTg)、促甲状腺激素(TSH)表达与甲状腺乳头状癌患者超声引导下射频消融预后的关系。方法回顾性分析2022年1月至2023年1月在河北省衡水市第二人民医院接受超声引导下射频消融治疗且预后较好的30例甲状腺乳头状癌患者纳入预后良好组,同期经超声引导下射频消融治疗但出现转移、复发的30例甲状腺乳头状癌患者纳入预后不良组,对比2组患者治疗前空腹血清中sTg和TSH水平,分析血清中sTg和TSH水平与超声引导下射频消融治疗预后的关系。结果预后不良组患者血清TSH和sTg表达水平均较预后良好组高(P<0.05)。Logistic回归模型结果显示,患者治疗前空腹血清TSH、sTg表达与甲状腺乳头状癌患者超声引导下射频消融治疗预后有关,血清TSH、sTg过表达可能是甲状腺乳头状癌患者超声引导下射频消融治疗预后不良的风险因子(OR>1,P<0.05);绘制ROC曲线结果显示:治疗前空腹血清TSH和sTg表达预测甲状腺乳头状癌患者超声引导下射频消融治疗预后不良风险的AUC均>0.80。依据ROC曲线得出患者治疗前空腹血清TSH≥1.870 mIU/L、sTg≥15.125μg/L时,甲状腺乳头状癌患者经超声引导下射频消融治疗预后不良的风险较高。结论甲状腺乳头状癌患者治疗前空腹血清TSH和sTg表达与超声引导下射频消融治疗预后有关,血清TSH和sTg过表达是导致患者预后不良的危险因素。Objective To observe the relationship between the expression of serum stimulated thyroglobulin(sTg),thyroid stimulating hormone(TSH)and the prognosis of patients with papillary thyroid cancer treated with ultrasound-guided radiofrequency ablation.Methods A retrospective analysis was conducted.30 patients with papillary thyroid cancer who received ultrasound-guided radiofrequency ablation in our hospital from January 2022 to January 2023 and had a good prognosis were included in the good prognosis group.30 patients with papillary thyroid cancer who underwent ultrasound-guided radiofrequency ablation but had metastasis and recurrence during the collection period were included in the poor prognosis group.The expression of sTg and TSH in fasting serum before treatment was compared between the two groups,and the relationship between the expression of sTg and TSH in serum and the prognosis of ultrasound-guided radiofrequency ablation was analyzed.Results The expression of serum TSH and sTg in the poor prognosis group was higher than that in the good prognosis group,and the difference was statistically significant(P<0.05);There was no significant difference in other data between the two groups(P>0.05);The results of logistic regression model showed that the expression of fasting serum TSH and sTg before treatment was related to the prognosis of patients with papillary thyroid cancer treated with ultrasound-guided radiofrequency ablation.The overexpression of serum TSH and sTg may be risk factors for poor prognosis of patients with papillary thyroid cancer treated with ultrasound-guided radiofrequency ablation(OR>1,P<0.05);The results of ROC curve showed that the AUC of fasting serum TSH and sTg expression before treatment to predict the risk of poor prognosis in patients with papillary thyroid cancer treated with ultrasound-guided radiofrequency ablation was>0.80.According to the ROC curve,the fasting serum TSH and sTg before treatment were≥1.870 mIU/L,≥15.125μg/L,the higher the risk of poor prognosis in patients w

关 键 词：甲状腺乳头状癌 促甲状腺激素 刺激性甲状腺球蛋白 超声引导下射频消融治疗 预测价值 

分 类 号：R736.1[医药卫生—肿瘤]