银杏内酯联合阿替普酶治疗急性脑梗死的疗效及对患者血清细胞因子的影响  

Efficacy of ginkgolides combined with alteplase in the treatment of acute cerebral infarction and its effects on serum serum cytokines

作　　者：何翼 江静如 HE Yi;JIANG Jing-ru(Department of Neurology,Anqing 116 Hospital,Anqing 246000,Anhui,China)

机构地区：[1]安庆一一六医院神经内科,安徽安庆246000

出　　处：《川北医学院学报》2024年第9期1238-1241,共4页Journal of North Sichuan Medical College

基　　金：安徽省安庆市科学技术局医疗卫生科技计划项目(2022Z4014)。

摘　　要：目的:探讨银杏内酯联合阿替普酶治疗急性脑梗死(ACI)的效果。方法:选择80例ACI患者为研究对象,按照治疗方式不同分为对照组与观察组,每组各40例。对照组予以阿替普酶溶栓治疗;观察组予以银杏内酯联合阿替普酶治疗,两组患者均治疗14 d。对两组患者行美国国立卫生研究卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分,完成改良Barthel指数(MBI)评估,并检测血清神经胶质纤维酸性蛋白(GFAP)、钙结合蛋白(S100β)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)水平;对比两组疗效和不良反应发生情况。结果:相较对照组,观察组治疗总有效率更高(90.00%vs.72.50%,P<0.05)。治疗后,观察组患者NIHSS、mRS评分低于对照组(P<0.05),MBI评分高于对照组(P<0.05),血清GFAP、S100-β、hs-CRP、IL-6水平低于对照组(P<0.05)。两组患者不良反应总发生率无统计学差异(P>0.05)。结论:银杏内酯联合阿替普酶治疗ACI患者可获得较好疗效,能够下调血清GFAP、S100-β和炎症因子水平,促进神经功能恢复。Objective:To investigate the effect of ginkgolides combined with alteplase in the treatment of acute cerebral infarction(ACI).Methods:80 ACI patients were divided into control group and observation group according to different treatment methods,40 cases in each group.The control group was treated with alteplase thrombolytic therapy,and the observation group was treated with ginkgolides combined with alteplase.Both groups were treated for 14 days.The National Institutes of Health Stroke Scale(NIHSS)score,modified Rankin Scale(mRS)score and modified Barthel Index(MBI)score were evaluated,and the levels of serum glial fibrillary acidic protein(GFAP),calcium binding protein(S100β),high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)were detected.The efficacy and adverse reactions of the two groups were compared.Results:The observation group's total effective rate was higher comparing with the control group(90.00%vs.72.50%,P<0.05).After treatment,the observation group's NIHSS,mRS scores were lower comparing with the control group(P<0.05),the MBI score was higher(P<0.05),and the serum levels of GFAP,S100-β,hs-CRP and IL-6 in the observation group were lower(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ginkgolides combined with alteplase can achieve better efficacy in the treatment of ACI patients,which can down-regulate the levels of serum GFAP,S100-βand inflammatory factors,and promote the recovery of neurological function.

关 键 词：急性脑梗死 银杏内酯注射液 阿替普酶 炎症因子 钙结合蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]