乳酸代谢与雄性生殖  

Lactate metabolism and male reproductive

作　　者：郝旭 董启启 原夏萌 曾文先 程佳 HAO Xu;DONG Qiqi;YUAN Xiameng;ZENG Wenxian;CHENG Jia(School of Biological Science and Engineering,Shaanxi University of Technology,Hanzhong 723001,China;Qinba State Key Laboratory of Biological Resources and Ecological Environment(Incubation),Shaanxi University of Technology,Hanzhong 723001,China)

机构地区：[1]陕西理工大学生物科学与工程学院,汉中723001 [2]陕西理工大学秦巴生物资源与生态环境省部共建重点实验室(培育),汉中723001

出　　处：《生命的化学》2024年第8期1319-1324,共6页Chemistry of Life

基　　金：陕西省科技厅项目(2024JC-YBMS-189);重点实验室“市校共建”科研专项(SXJ-2305)。

摘　　要：作为葡萄糖代谢的关键产物,乳酸在细胞代谢、信号转导、免疫调节中发挥重要作用。乳酸穿梭则是乳酸在生物体内发挥其功能多样性的重要转运机制。另外,乳酸化修饰的发现也为乳酸在生物体内的作用机制探究提供了新的视角。尽管乳酸在雄性生殖健康方面的研究相对较少,但它在这一生理过程中的潜在作用却不可忽视。本文以乳酸代谢为基础,通过对乳酸在精子的生成、成熟和功能方面的研究进行综述,旨在探讨乳酸对精子生命过程的影响,分析乳酸在雄性生殖中的作用,为乳酸在雄性生殖方面的研究提供一定参考。As a pivotal product of glucose metabolism,lactate plays a crucial role in cellular metabolism,signal transduction,and immune regulation.The lactate shuttle is a crucial transport mechanism that enables the diverse functions of lactate within organisms.Furthermore,the discovery of lactylation has provided a new avenue to explore the lactate′s function mechanisms.Despite the research on lactate in male reproduction has been relatively limited,its potential influence in male physiological process cannot be ignored.To shed light on the role of lactate in male reproduction,This work reviews the impact of lactate on sperm development,maturation,and functionality,which will offer preliminary insights into the lactate research in this domain.

关 键 词：乳酸 乳酸穿梭 乳酸化修饰 雄性生殖 

分 类 号：Q492[生物学—生理学]