非典型趋化因子受体的研究进展  

Research progress on atypical chemokine receptors

作　　者：许四宏[1,2,3] 黄钰 黄仕和 XU Sihong;HUANG Yu;HUANG Shihe(Division II of In Vitro Diagnostics for Infectious Diseases,Institute for In Vitro Diagnostics Control,National Institutes for Food and Drug Control,Beijing 100050,China;NMPA Key Laboratory for Quality Research and Evaluation of Medical Devices,Beijing 100050,China;NMPA Key Laboratory for Quality Research and Evaluation of In Vitro Diagnostics,Beijing 100050,China;Wuchang Shouyi CollegeWuhan 430064,China;Wuhan Institute of Biological Products Co.Ltd.,Wuhan 430207,China)

机构地区：[1]中国食品药品检定研究院体外诊断试剂检定所传染病诊断试剂二室,北京100050 [2]国家药品监督管理局医疗器械质量研究与国家重点实验室,北京100050 [3]国家药品监督管理局体外诊断试剂质量研究与国家重点实验室,北京100050 [4]武昌首义学院,武汉430064 [5]武汉生物制品研究所有限责任公司,武汉430207

出　　处：《生命的化学》2024年第8期1325-1337,共13页Chemistry of Life

摘　　要：非典型趋化因子受体(atypical chemokine receptors,ACKRs)指的是一类不能通过经典G蛋白进行信号转导的、具有七次跨膜结构域(TM1~TM7)的蛋白,分布于多种细胞、组织和器官;能结合多种配体,还能与经典趋化因子受体(conventional chemokine receptors,c CKRs)形成异源二聚体。ACKRs通过调节趋化因子的丰度、定位及可用性发挥着多种功能,包括趋化因子内吞、转胞吞、清除、提呈和贮存。ACKRs对正常人体的生物学功能的发挥及各种病理过程的发生发展均起着重要作用。本文就ACKRs亚家族的每个成员及其配体特征、功能及相互作用机制进行综述,以期为将来开发有效预防和治疗人体多种疾病的靶向药物提供参考。Atypical chemokine receptors(ACKRs)are seven-transmembrane domain-contained proteins that are unable to transduce signals through classical G-protein pathways.They are distributed throughout various cells,tissues,and organs,and are capable of binding to multiple ligands.Additionally,they can form heterodimers with cCKRs.ACKRs play various roles in modulating the abundance,localization,and availability of chemokines.The functions of ACKRs include chemokine endocytosis,transcytosis,scavenging,presentation,and reservoir.ACKRs play crucial roles in normal biological functions and the occurrence and development of various pathological conditions in human body.This review summarizes the characteristics,functions,and interaction mechanisms of each member of the ACKRs subfamily and their respective ligands.It provides a reference for the future development of targeted drugs for the effective prevention and treatment of various human diseases.

关 键 词：趋化因子 经典趋化因子受体 非典型趋化因子受体 β-阻遏蛋白 趋化作用 

分 类 号：R363[医药卫生—病理学]