白细胞计数、红细胞分布宽度、血小板计数/淋巴细胞计数比值联合检测在胃癌患者中的诊断价值  

Diagnosis Value of Combined Detection of White Blood Cell Count,Red Blood Cell Distribution Width,Platelet count/Lymphocyte Count Ratio in Patients with Gastric Cancer

作　　者：程金玲 罗影 吴瑞 CHENG Jin-ling;LUO Ying;WU Rui(Department of Medical Laboratory,Runan County People's Hospital,Zhumadian 463300,China)

机构地区：[1]汝南县人民医院医学检验科,驻马店463300

出　　处：《四川解剖学杂志》2024年第4期70-72,80,共4页Sichuan Journal of Anatomy

摘　　要：目的:探讨白细胞计数(WBC)、红细胞分布宽度(RDW)、血小板计数/淋巴细胞计数(PLR)联合检测在胃癌患者中的诊断价值.方法:选取2020年6月至2023年2月本院收治的128例胃癌患者为研究对象,纳入胃癌组;另选同期就诊的128例胃良性病变患者作为对照组.检测并比较两组患者入院时及不同病理学参数的WBC、RDW、PLR水平,分析相关性及诊断价值.结果:入院时胃癌组患者的WBC、RDW、PLR水平均显著高于对照组,差异有统计学意义(P<0.05).不同胃癌病理学参数的WBC、RDW、PLR水平比较:Ⅰ+Ⅱ期显著低于Ⅲ+Ⅳ期,高+中分化显著低于低分化,无淋巴结转移显著低于有淋巴结转移,差异有统计学意义(P<0.05).RDW、WBC、PLR水平与分化程度呈负相关,与肿瘤TNM分期、淋巴结转移均呈正相关,差异有统计学意义(P<0.05).WBC、RDW、PLR水平联合诊断胃癌的AUC为0.821,明显高于各单一指标诊断0.642、0.668、0.735,差异有统计学意义(P<0.05).结论:WBC、RDW、PLR与胃癌进展具有显著相关性,高水平WBC、RDW、PLR可作为早期胃癌诊断独立预测因子.Objective:To explore the diagnostic value of combined detection of white blood cell count(WBC),red blood cell distribution width(RDW),platelet count/lymphocyte count(PLR)in patients with gastric cancer.Methods:A total of 128 patients with gastric cancer admitted to our hospital from June 2020 to February 2023 were selected as gastric cancer group,and 128 patients with benign gastric lesions admitted to our hospital during the same period were selected as control group.The WBC,RDW,and PLR of the two groups at admission and with different pathological parameters were detected and compared.The correlation and diagnostic value were analyzed.Results:At admission,the levels of WBC,RDW and PLR in gastric cancer group were higher than those in control group,and the differences were statistically significant(P<0.05).The WBC,RDW and PLR levels of gastric cancer with different pathological parameters were significant:stage I+II was significantly lower than in stage II+IV,higher+middle differentiation was significantly lower than low differentiation,and no lymph node metastasis was significantly lower than that with lymph node metastasis,with statistical significance(P<0.05).RDW,WBC and PLR levels were negatively correlated with the degree of differentiation,and positively correlated with TNM stage and lymph node metastasis,with statistically significant differences(P<0.05).The AUC of combined WBC,RDW and PLR in the diagnosis of gastric cancer was 0.821,which was significantly higher than 0.642,0.668 and 0.735 in the diagnosis of each single index(P<O.05).Conclusion:WBC,RDW and PLR are significantly correlated with the progression of gastric cancer,and high levels of WBC,RDW and PLR can be used as independent predictors of early diagnosis of gastric cancer.

关 键 词：胃癌 白细胞计数 红细胞分布宽度 血小板计数/淋巴细胞计数比值 

分 类 号：R734.2[医药卫生—肿瘤]