RNA修饰在发育及相关疾病中的作用  

The regulation and roles of RNA modification in development and diseases

作　　者：朱岂凡 文俊飞 苟兰涛 ZHU Qifan;WEN Junfei;GOU Lantao(Key Laboratory of RNA Science and Engineering,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]中国科学院分子细胞科学卓越创新中心,中国科学院上海生物化学与细胞生物学研究所,核糖核酸功能与应用重点实验室,中国科学院大学,上海200031

出　　处：《生命的化学》2024年第9期1602-1619,共18页Chemistry of Life

基　　金：中国科学院战略先导科技专项B类(XDB0570000);国家重点研发计划项目(2021YFC2700200,2022YFC2702600);国家自然科学基金项目(32170815,U23A20402,32300459)。

摘　　要：目前已发现约170种RNA分子的化学修饰。已有证据表明,RNA修饰的动态调控对维持生物体内正常的RNA分子代谢至关重要。因此,RNA修饰的功能机制研究已成为当下最前沿的基础研究领域之一。本综述主要聚焦mRNA分子修饰(包括m6A、m5C、Ψ、ac4C及m7G)在生殖细胞发育、早期胚胎及器官发生中的调控作用,重点关注上述RNA修饰及其调控因子如何影响干细胞自我更新及细胞命运转变等关键发育生物学事件;并进一步探讨了RNA修饰调控蛋白功能障碍、修饰动态变化异常等与疾病发生发展之间的潜在联系;旨在为领域深入理解表观转录组调控与发育及人类疾病间的因果联系提供思路。To date,about 170 chemical modifications of RNA molecules have been identified.It has been demonstrated that the dynamic regulation of RNA modifications is essential for maintaining RNA metabolism.Therefore,investigating the dynamic regulation and functional mechanisms of these RNA modifications has become one of the cutting-edge fields.This review focuses on the regulatory roles of mRNA modifications(including m6A,m5C,Y,ac4C and m7G)in germ cell development,early embryo and organogenesis,with an emphasis on how the above mentioned RNA modifications and their regulatory factors affect key developmental biology events such as stem cell self-renewal and cell fate transitions.We further discuss the associations among dysfunction of RNA modification-associated proteins,aberrant changes in RNA modification dynamics,and development of diseases.The review aims to provide perspectives for further investigation of the correlation and causation among epitranscriptomic regulation,development and human diseases.

关 键 词：RNA修饰 生殖细胞发育 胚胎发育 器官发生 表观转录组学 

分 类 号：R363[医药卫生—病理学]