抗菌牙科粘接剂在龋病治疗中的研究进展  

Research progress of antibacterial dental adhesives in the treatment of caries

作　　者：张灵俊 章可可 孙妍 汪敏 郑高哲 潘乙怀 余杰 ZHANG Ling-jun;ZHANG Ke-ke;SUN Yan;WANG Min;ZHENG Gao-zhe;PAN Yi-huai;YU Jie(School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou 325000,China)

机构地区：[1]温州医科大学口腔医学院·附属口腔医院,浙江温州325000

出　　处：《牙体牙髓牙周病学杂志》2024年第6期350-355,共6页Chinese Journal of Conservative Dentistry

基　　金：国家卫生健康委员会科研基金-浙江卫生健康重大科技计划项目(WKJ-ZJ-2214);国家自然科学基金面上项目(82170950)。

摘　　要：牙科粘接剂在治疗细菌相关性疾病-龋齿过程中,发挥连接复合树脂及牙体组织的作用。通过对粘接剂进行改性,使其具备一定的抗菌功能,可有效抑制粘接界面细菌生长。本综述系统评估和总结了改性牙科粘接剂的各种策略,重点探讨包括金属及其化合物、季铵盐、天然抗菌药物、抗菌肽及载药系统等抗菌成分的应用前景。Dental adhesives play a crucial role in connecting composite resins to dental tissues during the treatment of bacteria-related diseases such as dental caries.By incorporating antimicrobial properties into modified dental adhesives,bacterial growth at the adhesive interface can be inhibited.This review systematically evaluates and summarizes various strategies of modified dental adhesives,focusing on the application prospects of antimicrobial agents including metals and their compounds,quaternary ammonium salts,natural antimicrobial agents,antimicrobial peptides,and drug delivery systems.

关 键 词：牙科粘接剂 龋病 抗菌 金属 季铵盐 抗菌肽 载药 

分 类 号：R781.4[医药卫生—口腔医学]