浓缩生长因子血纤维蛋白用于恒磨牙深龋直接盖髓术的临床研究  

Clinical study on the application of concentrated growth factor in direct pulp capping of permanent molar deep caries

作　　者：李睿敏[1,2] 杨娅凤 段丽 张钊萌 剡亚妹 丁小燕 LI Rui-min;YANG Ya-feng;DUAN Li;ZHANG Zhao-meng;YAN Ya-mei;DING Xiao-yan(Department of dental and endodontic diseases,stomatological hospital,General Hospital of Ningxia Medical University,Yinchuan 750000,China;不详)

机构地区：[1]宁夏医科大学总医院口腔医院牙体牙髓病科,宁夏银川750000 [2]宁夏医科大学口腔医学院,宁夏银川750000

出　　处：《牙体牙髓牙周病学杂志》2024年第5期277-281,共5页Chinese Journal of Conservative Dentistry

基　　金：宁夏回族自治区重点研发项目(2020BEG03029);中国牙病防治基金会种子基金项目(A2021-135)。

摘　　要：目的:将浓缩生长因子血纤维蛋白(CGF)作为盖髓材料应用于恒磨牙深龋去尽龋坏后穿髓的直接盖髓术(DPC)中,观察患牙术后反应,明确其作为盖髓材料的临床可行性。方法:选取2021年05月至2023年12月就诊于宁夏医科大学总医院口腔医院牙体牙髓病科诊断为恒磨牙深龋且去尽龋坏后穿髓、符合DPC治疗的患者。根据直接盖髓材料的不同以及患者意愿分为Dycal对照组和CGF试验组,两组除直接盖髓材料不同以外,垫底材料及充填材料均相同。术后1、3、6个月定期复查,观察2组术后反应及临床效果。结果:共有132例患牙纳入本研究,8例失访。Dycal对照组和CGF试验组各62例。治疗前出现牙齿敏感的患者在术后6个月复查时,Dycal对照组和CGF试验组牙齿敏感缓解情况分别为58.62%、71.92%,差异无统计学意义(P>0.05)。术后6个月,两组共成功115例,失败9例。两组总体成功率为92.74%,Dycal组和CGF组成功率分别为93.54%、91.93%,差异无统计学意义(P>0.05)。结论:将CGF作为盖髓剂用于恒磨牙去尽龋坏后穿髓的DPC可以达到保存生活牙髓,降低牙髓摘除率及根管治疗率的目的。AIM:The application of concentrated growth factor hemofibrin(CGF)as a pulp capping material in direct pulp capping(DPC)of permanent molars after deep caries removal and pulp piercing was investigated to determine the clinical feasibility of using CGF as a pulp capping material.METHODS:Patients who were diagnosed as permanent molar deep caries by the Department of Dentistry and Endodontics of the General Hospital of Ningxia Medical University from May 2021 to December 2023 and who had undergone thorough caries removal and pulp penetration were eligible for DPC treatment.According to different direct pulp capping materials and patient wishes,they were divided into Dycal control group and CGF test group.The base material and filling material were the same in both groups except for the direct pulp capping materials.Regular reexamination was conducted 1,3,and 6 months after surgery to observe the postoperative reactions and clinical effects of the two groups.RESULTS:A total of 132 patients with affected teeth were included in the study and 8 were lost to follow-up.Dycal control group and CGF test group were 62 cases each.Patients who have tooth sensitivity before treatment showd a 58.62%and 71.92%relief of tooth sensitivity in Dycal control group and CGF test group,respectively,at the re-examination 6 months after surgery,with no statistically significant difference(P>0.05).Six months after operation,115 cases were successful and 9 cases failed.The overall success rate of the two groups was 92.74%,and the success rate in Dycal group and CGF group was 93.54%and 91.93%,respectively,with no statistical significance(P>0.05).CONCLUSION:Using CGF as a pulp capping agent for DPC penetrating the pulp of permanent molars after complete caries removal can achieve the goal of preserving living pulp,reducing the rate of pulp removal and root canal treatment.

关 键 词：浓缩生长因子血纤维蛋白 DYCAL 恒磨牙 深龋 直接盖髓术 

分 类 号：R781.05[医药卫生—口腔医学]