玉米朊在药剂学中的应用进展  

Advance in application of Zein in pharmaceutics

作　　者：王晶 张锐 WANG Jing;ZHANG Rui(Zhongda Hospital of Southeast University,Nanjing 210009;Jiangxi University of Traditional Chinese Medicine,Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Nanchang 330004)

机构地区：[1]东南大学附属中大医院,南京210009 [2]江西中医药大学现代中药制剂教育部重点实验室,南昌330004

出　　处：《中南药学》2024年第9期2394-2397,共4页Central South Pharmacy

基　　金：国家自然科学基金项目(No.82360702,No.81560579,No.81160523);江西省重点研发计划(No.20224BBG71022);江西省教育厅科技项目(No.GJJ14609)。

摘　　要：玉米朊是从玉米中提取的一种醇溶性蛋白,已被《中国药典》收载。玉米朊因具有可再生、无毒、生物相容、可生物降解等特性,成为药物辅料的热门选择。玉米朊可以提高药物稳定性及口服生物利用度,控制药物释放,增强药物靶向性,从而有效提高药物疗效。此外,玉米朊含有游离的羟基和氨基,这些羟基和氨基提供了许多修饰位点,使其能够与其他材料杂交,以创建功能化的药物递送系统。本文旨在系统地介绍玉米朊的物理性质及其在药剂学上的应用,以促进其进一步开发利用。Zein is an alcohol soluble protein extracted from corns and has been included in the Chinese Pharmacopoeia.Zein is renewable,non-toxic,biocompatible,and biodegradable,making it a popular choice for pharmaceutical excipients.Zein can improve drug stability,enhance oral bioavailability,control drug release,enhance drug targeting,and effectively improve drug efficacy.In addition,Zein contains free hydroxyl and amino groups,which provide many modification sites to hybridize with other materials to create functional drug delivery systems.This article aimed to systematically introduce the physical properties of Zein and its applications in pharmaceutics to demonstrate its development potential and promote its further application.

关 键 词：玉米朊 药物辅料 物理性质 醇溶性蛋白 

分 类 号：R94[医药卫生—药剂学]